Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2523048..2523232 Replicon chromosome
Accession NZ_CP013218
Organism Staphylococcus aureus strain LA-MRSA ST398 isolate E154

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag AS852_RS13185 Protein ID WP_000482647.1
Coordinates 2523125..2523232 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2523048..2523108 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AS852_RS13160 2518502..2518669 - 168 WP_001798790.1 hypothetical protein -
AS852_RS13170 2518900..2520633 - 1734 WP_000486511.1 ABC transporter ATP-binding protein/permease -
AS852_RS13175 2520658..2522421 - 1764 WP_001064818.1 ABC transporter ATP-binding protein/permease -
- 2523048..2523108 + 61 - - Antitoxin
AS852_RS13185 2523125..2523232 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
AS852_RS13190 2523366..2523752 - 387 WP_000779355.1 flippase GtxA -
AS852_RS13195 2524019..2525161 + 1143 WP_001176859.1 glycerate kinase -
AS852_RS13200 2525221..2525880 + 660 WP_000831300.1 hypothetical protein -
AS852_RS13205 2526068..2527279 + 1212 WP_001191974.1 multidrug effflux MFS transporter -
AS852_RS13210 2527402..2527875 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T58130 WP_000482647.1 NZ_CP013218:c2523232-2523125 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T58130 NZ_CP013218:c2523232-2523125 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT58130 NZ_CP013218:2523048-2523108 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References