Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-SprA2AS/-
Location 2227248..2227446 Replicon chromosome
Accession NZ_CP013218
Organism Staphylococcus aureus strain LA-MRSA ST398 isolate E154

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag AS852_RS11575 Protein ID WP_001802298.1
Coordinates 2227342..2227446 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2227248..2227286 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AS852_RS11555 2223368..2224033 - 666 WP_001024099.1 SDR family oxidoreductase -
AS852_RS11560 2224185..2224505 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
AS852_RS11565 2224507..2225487 + 981 WP_000019735.1 CDF family zinc efflux transporter CzrB -
AS852_RS11570 2225753..2226844 + 1092 WP_000495673.1 hypothetical protein -
- 2227248..2227286 + 39 - - Antitoxin
AS852_RS11575 2227342..2227446 - 105 WP_001802298.1 hypothetical protein Toxin
AS852_RS15305 2227963..2228133 + 171 WP_001807897.1 hypothetical protein -
AS852_RS11590 2228126..2228284 + 159 WP_001792784.1 hypothetical protein -
AS852_RS11595 2228720..2228812 + 93 WP_000220902.1 hypothetical protein -
AS852_RS11600 2228942..2229799 - 858 WP_000370942.1 Cof-type HAD-IIB family hydrolase -
AS852_RS11605 2229867..2230649 - 783 WP_000908191.1 ABC transporter ATP-binding protein -
AS852_RS11610 2230939..2231547 - 609 WP_000101714.1 TIR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T58129 WP_001802298.1 NZ_CP013218:c2227446-2227342 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T58129 NZ_CP013218:c2227446-2227342 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 39 bp

>AT58129 NZ_CP013218:2227248-2227286 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References