Detailed information of TA system TA058026

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1849222..1849529
• Replicon: chromosome
• Accession: NZ_CP013182
• Organism: Staphylococcus aureus strain SA40TW

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SA40TW_RS09315
• Protein ID: WP_011447039.1
• Coordinates: 1849353..1849529 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1849222..1849361 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA40TW_RS09255	1844789..1844968	+	180	WP_000669791.1	hypothetical protein	-
SA40TW_RS09265	1845279..1845539	+	261	WP_001791826.1	hypothetical protein	-
SA40TW_RS09270	1845592..1845942	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SA40TW_RS09275	1846452..1846787	-	336	Protein_1711	SH3 domain-containing protein	-
SA40TW_RS09295	1847438..1847929	-	492	WP_000920038.1	staphylokinase	-
SA40TW_RS09300	1848120..1848875	-	756	WP_000861038.1	CHAP domain-containing protein	-
SA40TW_RS09305	1848887..1849141	-	255	WP_000611512.1	phage holin	-
SA40TW_RS09310	1849193..1849300	+	108	WP_031762631.1	hypothetical protein	-
-	1849222..1849361	+	140	NuclAT_0	-	Antitoxin
-	1849222..1849361	+	140	NuclAT_0	-	Antitoxin
-	1849222..1849361	+	140	NuclAT_0	-	Antitoxin
-	1849222..1849361	+	140	NuclAT_0	-	Antitoxin
SA40TW_RS09315	1849353..1849529	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SA40TW_RS09320	1849732..1850505	-	774	WP_025174055.1	staphylococcal enterotoxin type P	-
SA40TW_RS09325	1850926..1851300	-	375	WP_000340977.1	hypothetical protein	-
SA40TW_RS09330	1851356..1851643	-	288	WP_001040255.1	hypothetical protein	-
SA40TW_RS09335	1851690..1851842	-	153	WP_000654329.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / see	1842722..1894391	51669

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T58026 WP_011447039.1 NZ_CP013182:c1849529-1849353 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T58026 NZ_CP013182:c1849529-1849353 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT58026 NZ_CP013182:1849222-1849361 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin