Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 4122279..4122912 Replicon chromosome
Accession NZ_CP013145
Organism Colwellia sp. MT41

Toxin (Protein)


Gene name higB Uniprot ID A0A0S2JFW6
Locus tag CMT41_RS17455 Protein ID WP_057183197.1
Coordinates 4122580..4122912 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1Z5I4P3
Locus tag CMT41_RS17450 Protein ID WP_057183175.1
Coordinates 4122279..4122593 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CMT41_RS17430 4117893..4118510 - 618 WP_058027979.1 hypothetical protein -
CMT41_RS17435 4118807..4120060 - 1254 WP_157466430.1 dipeptidase -
CMT41_RS17440 4120244..4120786 - 543 WP_058027980.1 hypothetical protein -
CMT41_RS17445 4120977..4121681 - 705 WP_058027981.1 HupE/UreJ family protein -
CMT41_RS17450 4122279..4122593 - 315 WP_057183175.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
CMT41_RS17455 4122580..4122912 - 333 WP_057183197.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CMT41_RS17460 4123052..4123624 + 573 WP_058027982.1 site-specific integrase -
CMT41_RS17465 4123682..4124248 + 567 WP_198149762.1 transposase -
CMT41_RS17470 4124535..4125062 - 528 WP_197410308.1 acetyltransferase -
CMT41_RS17475 4125056..4125235 - 180 WP_057183181.1 hypothetical protein -
CMT41_RS17480 4125623..4126543 + 921 WP_058027984.1 site-specific integrase -
CMT41_RS19275 4126536..4127102 + 567 WP_058027985.1 transposase zinc-binding domain-containing protein -
CMT41_RS19280 4127038..4127382 + 345 WP_198149763.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(8-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12904.99 Da        Isoelectric Point: 10.2228

>T58022 WP_057183197.1 NZ_CP013145:c4122912-4122580 [Colwellia sp. MT41]
MKCIFVESKIFEKYRDDHLSDEEFRLFQAELMSNPKKGDVIQGTGGLRKVRVASKGKGKRGGSRVIYYFLDKKRRCYLLP
IYGKSEMSDLTADQKKQLKVFMEVWRNEQS

Download         Length: 333 bp

>T58022 NZ_CP013145:c4122912-4122580 [Colwellia sp. MT41]
ATGAAATGTATATTTGTAGAATCAAAAATATTTGAGAAATACCGAGATGACCACCTCAGTGATGAAGAGTTTAGACTGTT
TCAAGCTGAGCTAATGTCAAACCCGAAGAAGGGTGATGTGATTCAAGGTACTGGTGGTTTGCGGAAGGTTCGAGTTGCAA
GTAAGGGTAAAGGAAAACGTGGTGGTTCCCGTGTTATTTATTACTTCCTTGATAAAAAGCGACGTTGCTATTTACTTCCT
ATTTATGGAAAAAGTGAAATGTCGGATTTAACCGCAGATCAAAAGAAACAGTTAAAGGTTTTTATGGAGGTATGGCGTAA
TGAGCAATCGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11738.23 Da        Isoelectric Point: 6.6066

>AT58022 WP_057183175.1 NZ_CP013145:c4122593-4122279 [Colwellia sp. MT41]
MSNRDLFTELSSALVEAKEHSEGKITLKTHHVNDVSELDISPNEIVHIREKFNMSRGVFASLLHTSSRTLENWEQGRSAP
NGQAITLLKLVQRHPETLTHIAEL

Download         Length: 315 bp

>AT58022 NZ_CP013145:c4122593-4122279 [Colwellia sp. MT41]
ATGAGCAATCGTGATTTATTTACAGAATTAAGTTCCGCTCTTGTTGAAGCAAAAGAACATTCAGAGGGGAAAATCACCCT
TAAAACGCATCATGTCAACGATGTAAGTGAACTTGATATTTCACCTAATGAAATTGTACATATTAGAGAAAAATTTAATA
TGTCACGTGGTGTGTTTGCTAGTTTGCTTCATACATCTTCTCGTACGTTAGAGAACTGGGAGCAAGGACGCAGTGCTCCA
AATGGGCAAGCAATAACACTTTTGAAATTAGTGCAACGTCATCCAGAAACTCTCACGCACATTGCAGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S2JFW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z5I4P3

References