Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3951410..3952137 Replicon chromosome
Accession NZ_CP013145
Organism Colwellia sp. MT41

Toxin (Protein)


Gene name higB Uniprot ID A0A0S2JLB2
Locus tag CMT41_RS16720 Protein ID WP_057182896.1
Coordinates 3951410..3951721 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S2JK61
Locus tag CMT41_RS16725 Protein ID WP_058027899.1
Coordinates 3951721..3952137 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CMT41_RS16705 3947286..3948197 + 912 WP_057183658.1 site-specific integrase -
CMT41_RS16710 3948190..3949254 + 1065 WP_057183656.1 IS91 family transposase -
CMT41_RS16715 3949536..3950333 - 798 WP_157466392.1 hypothetical protein -
CMT41_RS16720 3951410..3951721 + 312 WP_057182896.1 type II toxin-antitoxin system HigB family toxin Toxin
CMT41_RS16725 3951721..3952137 + 417 WP_058027899.1 helix-turn-helix domain-containing protein Antitoxin
CMT41_RS16730 3952361..3952630 - 270 Protein_3316 MarR family transcriptional regulator -
CMT41_RS16735 3952842..3953264 + 423 WP_058027900.1 organic hydroperoxide resistance protein -
CMT41_RS16740 3953315..3953704 + 390 WP_057182902.1 DoxX family protein -
CMT41_RS16745 3954137..3955036 - 900 WP_057182904.1 DNA-binding transcriptional regulator OxyR -
CMT41_RS16750 3955124..3955741 - 618 WP_058027901.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Antitoxin HigA

(2-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12364.33 Da        Isoelectric Point: 10.2711

>T58021 WP_057182896.1 NZ_CP013145:3951410-3951721 [Colwellia sp. MT41]
MHVIARKIFSDAMKKFSNDADAIEDLYRLLNSGKFKEPSELKKVTPSLDNFKYKDKWWMIDIGGNNLRLIAFIEFRHNRV
YVRHIVSHAEYDKLTTRYRKKEL

Download         Length: 312 bp

>T58021 NZ_CP013145:3951410-3951721 [Colwellia sp. MT41]
ATGCACGTAATAGCTAGAAAAATTTTCAGTGATGCTATGAAAAAATTTTCCAATGATGCAGATGCTATTGAGGATTTATA
CAGACTACTTAATAGCGGTAAATTCAAAGAACCAAGTGAATTAAAAAAAGTAACACCTTCTTTAGATAATTTTAAATATA
AAGATAAATGGTGGATGATCGATATTGGCGGTAATAACTTGAGGTTAATTGCATTTATTGAGTTTCGTCATAACCGTGTG
TACGTAAGACATATTGTTAGCCACGCAGAATACGATAAATTAACTACACGCTATAGAAAAAAGGAACTGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15672.69 Da        Isoelectric Point: 4.2340

>AT58021 WP_058027899.1 NZ_CP013145:3951721-3952137 [Colwellia sp. MT41]
MNIQHITDLAQQLQNEMPFITGINSAQENEAALELINELTDDYDNNLLLIDVLWAKIEDYENNASELAAFNQRIENLNNG
SSMLRLLMVQHGLNTTSFAQEIGGKSTVSMIFNEKRKLTVEHIEKLSARFEISPALFF

Download         Length: 417 bp

>AT58021 NZ_CP013145:3951721-3952137 [Colwellia sp. MT41]
ATGAATATTCAACATATAACAGATCTTGCTCAACAGCTTCAAAATGAAATGCCCTTTATTACTGGCATTAATTCAGCACA
AGAAAACGAAGCTGCATTAGAATTGATTAATGAATTAACAGATGATTATGATAACAACTTATTATTGATTGATGTTCTAT
GGGCTAAAATTGAAGATTATGAAAATAATGCTTCTGAATTAGCAGCGTTTAATCAACGCATAGAAAATCTAAATAATGGC
TCTTCAATGTTACGTTTGTTGATGGTTCAACACGGATTAAATACAACGTCCTTTGCTCAAGAAATTGGTGGAAAGAGCAC
AGTCTCTATGATTTTCAATGAGAAACGGAAATTAACAGTAGAACACATTGAAAAATTATCAGCCCGATTCGAAATCAGCC
CTGCTCTATTCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S2JLB2

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2JK61

References