Detailed information of TA system TA058008

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2020501..2021024
• Replicon: chromosome
• Accession: NZ_CP013137
• Organism: Staphylococcus aureus strain XQ

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: ASU36_RS10550
• Protein ID: WP_058008230.1
• Coordinates: 2020501..2020767 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2S6D1W5
• Locus tag: ASU36_RS10555
• Protein ID: WP_000587617.1
• Coordinates: 2020767..2021024 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASU36_RS10530	2015711..2016898	-	1188	WP_058008228.1	MFS transporter	-
ASU36_RS10535	2017293..2018069	-	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
ASU36_RS10540	2018062..2018724	-	663	WP_000923514.1	ATP-binding cassette domain-containing protein	-
ASU36_RS10545	2019069..2020145	-	1077	WP_001076675.1	M42 family metallopeptidase	-
ASU36_RS10550	2020501..2020767	-	267	WP_058008230.1	Txe/YoeB family addiction module toxin	Toxin
ASU36_RS10555	2020767..2021024	-	258	WP_000587617.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ASU36_RS10565	2021384..2021839	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
ASU36_RS10570	2022007..2023584	-	1578	WP_000971447.1	FMN-binding glutamate synthase family protein	-
ASU36_RS10575	2023779..2024528	+	750	WP_000072454.1	CPBP family intramembrane metalloprotease	-
ASU36_RS10580	2024752..2025945	-	1194	WP_000675402.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10708.33 Da
• Isoelectric Point: 10.1384

>T58008 WP_058008230.1 NZ_CP013137:c2020767-2020501 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHFYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T58008 NZ_CP013137:c2020767-2020501 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTTTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9747.71 Da
• Isoelectric Point: 4.1353

>AT58008 WP_000587617.1 NZ_CP013137:c2021024-2020767 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT58008 NZ_CP013137:c2021024-2020767 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2S6D1W5