58005

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1963678..1964195 Replicon chromosome
Accession NZ_CP013137
Organism Staphylococcus aureus strain XQ

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag ASU36_RS10255 Protein ID WP_000113263.1
Coordinates 1963678..1963944 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ASU36_RS10260 Protein ID WP_000584499.1
Coordinates 1963944..1964195 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASU36_RS10225 1958776..1959312 - 537 WP_000185898.1 GNAT family N-acetyltransferase -
ASU36_RS10235 1959890..1960714 - 825 WP_000594640.1 formate/nitrite transporter family protein -
ASU36_RS10240 1960917..1961099 - 183 WP_000079140.1 hypothetical protein -
ASU36_RS10245 1961186..1961653 - 468 WP_000153349.1 SRPBCC domain-containing protein -
ASU36_RS10250 1961838..1963385 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ASU36_RS10255 1963678..1963944 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
ASU36_RS10260 1963944..1964195 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASU36_RS10265 1964360..1964460 - 101 Protein_1926 hypothetical protein -
ASU36_RS10270 1964467..1965066 - 600 WP_000162805.1 DsbA family protein -
ASU36_RS10275 1965085..1965447 - 363 WP_058008220.1 DUF4467 domain-containing protein -
ASU36_RS10280 1965702..1966952 + 1251 WP_001012216.1 FemA/FemB family glycyltransferase FmhA -
ASU36_RS10285 1967049..1967780 - 732 WP_000615459.1 amino acid ABC transporter ATP-binding protein -
ASU36_RS10290 1967777..1968496 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T58005 WP_000113263.1 NZ_CP013137:c1963944-1963678 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T58005 NZ_CP013137:c1963944-1963678 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT58005 WP_000584499.1 NZ_CP013137:c1964195-1963944 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT58005 NZ_CP013137:c1964195-1963944 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References