Detailed information of TA system TA057993

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1039509..1040088
• Replicon: chromosome
• Accession: NZ_CP013137
• Organism: Staphylococcus aureus strain XQ

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: ASU36_RS05120
• Protein ID: WP_001025401.1
• Coordinates: 1039843..1040088 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1039509..1039874 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASU36_RS05080	1036252..1036809	-	558	WP_058008067.1	DUF2815 family protein	-
ASU36_RS05085	1036835..1038001	-	1167	WP_058008068.1	DUF2800 domain-containing protein	-
ASU36_RS05090	1037998..1038360	-	363	WP_000985984.1	hypothetical protein	-
ASU36_RS05095	1038375..1038698	-	324	WP_031773431.1	hypothetical protein	-
ASU36_RS05100	1038777..1038938	-	162	WP_001285955.1	DUF1270 family protein	-
ASU36_RS05105	1038951..1039214	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
ASU36_RS05110	1039239..1039454	-	216	WP_001097552.1	hypothetical protein	-
ASU36_RS05115	1039509..1039874	+	366	WP_001128433.1	hypothetical protein	Antitoxin
ASU36_RS05120	1039843..1040088	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
ASU36_RS05125	1040144..1040353	+	210	WP_000642492.1	hypothetical protein	-
ASU36_RS05130	1040343..1040486	-	144	WP_000939498.1	hypothetical protein	-
ASU36_RS05135	1040515..1041291	-	777	WP_001148544.1	Rha family transcriptional regulator	-
ASU36_RS05140	1041305..1041541	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
ASU36_RS05145	1041693..1042007	+	315	WP_058008071.1	helix-turn-helix domain-containing protein	-
ASU36_RS05150	1042020..1042481	+	462	WP_000525004.1	hypothetical protein	-
ASU36_RS05155	1042499..1043083	+	585	WP_000825948.1	hypothetical protein	-
ASU36_RS05160	1043313..1043459	+	147	WP_001013104.1	hypothetical protein	-
ASU36_RS05165	1043456..1044069	-	614	Protein_1003	ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV / gnd	997030..1067996	70966

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T57993 WP_001025401.1 NZ_CP013137:c1040088-1039843 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T57993 NZ_CP013137:c1040088-1039843 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT57993 NZ_CP013137:1039509-1039874 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin