Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1183330..1184593 Replicon chromosome
Accession NZ_CP013131
Organism Porphyromonas gingivalis A7A1-28

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag PGS_RS05060 Protein ID WP_058019480.1
Coordinates 1183330..1184265 (-) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag PGS_RS05065 Protein ID WP_058019026.1
Coordinates 1184258..1184593 (-) Length 112 a.a.

Genomic Context

PGS_RS05080PGS_RS05085PGS_RS05045PGS_RS05050PGS_RS05055PGS_RS05060PGS_RS05065PGS_RS05070PGS_RS05075
Location: 1186749..1187834 (1086 bp)
Type: Others
Protein ID: WP_058019029.1
Location: 1188931..1189272 (342 bp)
Type: Others
Protein ID: WP_010956332.1
Location: 1178787..1179920 (1134 bp)
Type: Others
Protein ID: WP_058019023.1
Location: 1179924..1182908 (2985 bp)
Type: Others
Protein ID: WP_058019024.1
Location: 1182940..1183260 (321 bp)
Type: Others
Protein ID: WP_058019025.1
Location: 1183330..1184265 (936 bp)
Type: Toxin
Protein ID: WP_058019480.1
Location: 1184258..1184593 (336 bp)
Type: Antitoxin
Protein ID: WP_058019026.1
Location: 1184590..1184814 (225 bp)
Type: Others
Protein ID: WP_058019027.1
Location: 1184976..1186124 (1149 bp)
Type: Others
Protein ID: WP_058019028.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PGS_RS050451178787..1179920-1134WP_058019023.1AAA family ATPase-
PGS_RS050501179924..1182908-2985WP_058019024.1type I restriction endonuclease subunit R-
PGS_RS050551182940..1183260-321WP_058019025.1helix-turn-helix domain-containing protein-
PGS_RS050601183330..1184265-936WP_058019480.1HipA domain-containing proteinToxin
PGS_RS050651184258..1184593-336WP_058019026.1HipA N-terminal domain-containing proteinAntitoxin
PGS_RS050701184590..1184814-225WP_058019027.1helix-turn-helix transcriptional regulator-
PGS_RS050751184976..1186124-1149WP_058019028.1Fic family protein-
PGS_RS050801186749..1187834+1086WP_058019029.1IS5 family transposase-
PGS_RS050851188931..1189272+342WP_010956332.1helix-turn-helix domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(55-279)

Antitoxin

HipA, N-terminal subdomain 1

(6-101)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 36253.93 Da        Isoelectric Point: 6.4927

>T57972 WP_058019480.1 NZ_CP013131:c1184265-1183330 [Porphyromonas gingivalis A7A1-28]
MNRCLYCYEPLVDREEDYHAKCCRKLFGMPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLFLDFDQMSHSPKRFTIV
GLWGRFILKPQTERYPHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTEY
KYKGSHEQIAKLITKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPIGNEYQLTPAYDLLSTSLVIPEDTEELA
LTLCGKKRKLTRQHFLEAMTASGLDEKVCDNIFARFQRILPEWETCIRQSFLPGEMQRQYIEFILLKFSQI

Download         Length: 936 bp

>T57972 NZ_CP013131:c1184265-1183330 [Porphyromonas gingivalis A7A1-28]
ATGAATAGATGCCTATATTGCTACGAACCTTTGGTTGATAGAGAGGAGGATTACCATGCCAAGTGTTGCCGCAAATTGTT
TGGGATGCCCCAAGCGCCGATATTGCCTTATACAAGTAGTGAGGTACGAGCATTGGCTGACGAGGTTGTTCGTTCGCAGA
CCACAGTGACAGGAGTACAACCCAAGCTCTTTCTTGACTTTGATCAGATGAGCCATTCCCCCAAGCGATTTACCATTGTG
GGCTTATGGGGGCGATTTATTCTTAAACCTCAAACGGAGCGTTATCCGCATCTCCCCGAATTGGAGGATGTGTCGATGCA
CCTTGCGGAGATTGCCAAGATTGAAACAGTTCCTCATGGACTGATGCGATTCAGCGATGGCGAACTATGCTACATCACTC
GTCGCATAGACCGAACAGGGCAAGGGGAAAAGCTCCCAATGGAAGATATGTGTCAGTTGTCAGAGCGCTTAACGGAGTAT
AAATACAAAGGCTCACACGAACAGATAGCCAAGCTGATCACCAAGTATAGCTCTGTGCCGAAGCTTGATCTTGTCAAGTA
TTGGGAGCAAGTCCTCTTTTCGTGGTTGATAGGTAATGCCGATATGCACCTCAAGAATTACTCGCTCTATGCGCCAATAG
GAAACGAATATCAACTAACACCCGCCTACGACCTGCTGTCTACGTCACTTGTTATTCCTGAGGATACAGAAGAACTTGCA
TTGACACTCTGTGGCAAAAAGCGCAAACTCACTCGACAACACTTCCTCGAAGCGATGACAGCCTCTGGATTGGATGAGAA
AGTGTGTGACAACATCTTCGCTCGCTTCCAACGTATCCTCCCCGAATGGGAAACCTGCATCCGACAGAGCTTTCTTCCTG
GGGAGATGCAGAGGCAATACATCGAATTCATTCTCCTCAAATTCTCTCAAATCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12646.54 Da        Isoelectric Point: 4.3952

>AT57972 WP_058019026.1 NZ_CP013131:c1184593-1184258 [Porphyromonas gingivalis A7A1-28]
MKQAIVYWKTLKAGILTESDEGYSFAYDKVYLTMPEAQSISLTMPLREEPFQSNTLHPFFDGLIPEGWLLDIAQKNWKID
ARDRMALLLACCRDCIGAVSIKPLNTTEDDE

Download         Length: 336 bp

>AT57972 NZ_CP013131:c1184593-1184258 [Porphyromonas gingivalis A7A1-28]
ATGAAGCAGGCTATTGTTTACTGGAAGACACTTAAGGCAGGCATTCTCACAGAAAGTGATGAGGGCTATTCCTTTGCTTA
TGACAAGGTCTATCTGACTATGCCTGAAGCTCAAAGCATAAGCCTGACAATGCCTTTGCGAGAGGAACCTTTCCAAAGTA
ATACTCTTCATCCATTCTTTGATGGACTTATCCCTGAGGGATGGCTTTTAGATATAGCCCAAAAGAATTGGAAAATAGAT
GCAAGGGATCGCATGGCGTTATTGTTGGCTTGTTGCCGAGACTGTATTGGGGCGGTAAGTATTAAACCTCTAAATACGAC
TGAAGATGATGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References