57972

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1183330..1184593 Replicon chromosome
Accession NZ_CP013131
Organism Porphyromonas gingivalis A7A1-28

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag PGS_RS05060 Protein ID WP_058019480.1
Coordinates 1183330..1184265 (-) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag PGS_RS05065 Protein ID WP_058019026.1
Coordinates 1184258..1184593 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGS_RS05045 1178787..1179920 - 1134 WP_058019023.1 AAA family ATPase -
PGS_RS05050 1179924..1182908 - 2985 WP_058019024.1 type I restriction endonuclease subunit R -
PGS_RS05055 1182940..1183260 - 321 WP_058019025.1 helix-turn-helix domain-containing protein -
PGS_RS05060 1183330..1184265 - 936 WP_058019480.1 HipA domain-containing protein Toxin
PGS_RS05065 1184258..1184593 - 336 WP_058019026.1 HipA N-terminal domain-containing protein Antitoxin
PGS_RS05070 1184590..1184814 - 225 WP_058019027.1 helix-turn-helix transcriptional regulator -
PGS_RS05075 1184976..1186124 - 1149 WP_058019028.1 Fic family protein -
PGS_RS05080 1186749..1187834 + 1086 WP_058019029.1 IS5 family transposase -
PGS_RS05085 1188931..1189272 + 342 WP_010956332.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(55-279)

Antitoxin

HipA, N-terminal subdomain 1

(6-101)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 36253.93 Da        Isoelectric Point: 6.4927

>T57972 WP_058019480.1 NZ_CP013131:c1184265-1183330 [Porphyromonas gingivalis A7A1-28]
MNRCLYCYEPLVDREEDYHAKCCRKLFGMPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLFLDFDQMSHSPKRFTIV
GLWGRFILKPQTERYPHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTEY
KYKGSHEQIAKLITKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPIGNEYQLTPAYDLLSTSLVIPEDTEELA
LTLCGKKRKLTRQHFLEAMTASGLDEKVCDNIFARFQRILPEWETCIRQSFLPGEMQRQYIEFILLKFSQI

Download         Length: 936 bp

>T57972 NZ_CP013131:c1184265-1183330 [Porphyromonas gingivalis A7A1-28]
ATGAATAGATGCCTATATTGCTACGAACCTTTGGTTGATAGAGAGGAGGATTACCATGCCAAGTGTTGCCGCAAATTGTT
TGGGATGCCCCAAGCGCCGATATTGCCTTATACAAGTAGTGAGGTACGAGCATTGGCTGACGAGGTTGTTCGTTCGCAGA
CCACAGTGACAGGAGTACAACCCAAGCTCTTTCTTGACTTTGATCAGATGAGCCATTCCCCCAAGCGATTTACCATTGTG
GGCTTATGGGGGCGATTTATTCTTAAACCTCAAACGGAGCGTTATCCGCATCTCCCCGAATTGGAGGATGTGTCGATGCA
CCTTGCGGAGATTGCCAAGATTGAAACAGTTCCTCATGGACTGATGCGATTCAGCGATGGCGAACTATGCTACATCACTC
GTCGCATAGACCGAACAGGGCAAGGGGAAAAGCTCCCAATGGAAGATATGTGTCAGTTGTCAGAGCGCTTAACGGAGTAT
AAATACAAAGGCTCACACGAACAGATAGCCAAGCTGATCACCAAGTATAGCTCTGTGCCGAAGCTTGATCTTGTCAAGTA
TTGGGAGCAAGTCCTCTTTTCGTGGTTGATAGGTAATGCCGATATGCACCTCAAGAATTACTCGCTCTATGCGCCAATAG
GAAACGAATATCAACTAACACCCGCCTACGACCTGCTGTCTACGTCACTTGTTATTCCTGAGGATACAGAAGAACTTGCA
TTGACACTCTGTGGCAAAAAGCGCAAACTCACTCGACAACACTTCCTCGAAGCGATGACAGCCTCTGGATTGGATGAGAA
AGTGTGTGACAACATCTTCGCTCGCTTCCAACGTATCCTCCCCGAATGGGAAACCTGCATCCGACAGAGCTTTCTTCCTG
GGGAGATGCAGAGGCAATACATCGAATTCATTCTCCTCAAATTCTCTCAAATCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12646.54 Da        Isoelectric Point: 4.3952

>AT57972 WP_058019026.1 NZ_CP013131:c1184593-1184258 [Porphyromonas gingivalis A7A1-28]
MKQAIVYWKTLKAGILTESDEGYSFAYDKVYLTMPEAQSISLTMPLREEPFQSNTLHPFFDGLIPEGWLLDIAQKNWKID
ARDRMALLLACCRDCIGAVSIKPLNTTEDDE

Download         Length: 336 bp

>AT57972 NZ_CP013131:c1184593-1184258 [Porphyromonas gingivalis A7A1-28]
ATGAAGCAGGCTATTGTTTACTGGAAGACACTTAAGGCAGGCATTCTCACAGAAAGTGATGAGGGCTATTCCTTTGCTTA
TGACAAGGTCTATCTGACTATGCCTGAAGCTCAAAGCATAAGCCTGACAATGCCTTTGCGAGAGGAACCTTTCCAAAGTA
ATACTCTTCATCCATTCTTTGATGGACTTATCCCTGAGGGATGGCTTTTAGATATAGCCCAAAAGAATTGGAAAATAGAT
GCAAGGGATCGCATGGCGTTATTGTTGGCTTGTTGCCGAGACTGTATTGGGGCGGTAAGTATTAAACCTCTAAATACGAC
TGAAGATGATGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References