Detailed information of TA system TA057968

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3357732..3358294
• Replicon: chromosome
• Accession: NZ_CP013126
• Organism: Acidipropionibacterium acidipropionici strain CGMCC 1.2230

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: ASQ49_RS15190
• Protein ID: WP_076692624.1
• Coordinates: 3357732..3357965 (+)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: ASQ49_RS15195
• Protein ID: WP_015069931.1
• Coordinates: 3357989..3358294 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASQ49_RS15170	3353157..3354290	-	1134	WP_015069935.1	glycosyltransferase	-
ASQ49_RS15175	3354295..3354621	-	327	WP_148279616.1	RDD family protein	-
ASQ49_RS15180	3354753..3356042	-	1290	WP_015069933.1	hypothetical protein	-
ASQ49_RS15185	3356255..3357676	+	1422	WP_015069932.1	type I glutamate--ammonia ligase	-
ASQ49_RS15190	3357732..3357965	+	234	WP_076692624.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ASQ49_RS15195	3357989..3358294	+	306	WP_015069931.1	HigA family addiction module antidote protein	Antitoxin
ASQ49_RS15205	3358896..3359912	-	1017	WP_015069930.1	YdcF family protein	-
ASQ49_RS15210	3360037..3360855	+	819	WP_028701670.1	Nif3-like dinuclear metal center hexameric protein	-
ASQ49_RS15215	3360863..3362155	+	1293	WP_076692623.1	threonine/serine exporter family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (19-77)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-72)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8578.58 Da
• Isoelectric Point: 6.6970

>T57968 WP_076692624.1 NZ_CP013126:3357732-3357965 [Acidipropionibacterium acidipropionici]
IIRPCCQHFTNGSTGGLVRLLNAASELNSPRVPPGNRLEKLVGGRDGQHSIRINDQYRICFVWTDNGADDVEITDYH

Nucleotide

• Length: 234 bp

>T57968 NZ_CP013126:3357732-3357965 [Acidipropionibacterium acidipropionici]
ATCATCCGCCCGTGCTGCCAGCACTTCACCAACGGCAGCACGGGCGGACTCGTTCGCCTCCTCAACGCGGCCTCAGAACT
GAACAGCCCTCGGGTGCCGCCGGGAAATCGCTTGGAGAAGCTGGTCGGCGGCCGCGACGGCCAGCACTCCATCCGCATCA
ACGACCAGTACCGAATCTGCTTCGTGTGGACCGACAACGGAGCAGACGACGTCGAGATCACCGACTATCACTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11168.69 Da
• Isoelectric Point: 4.8182

>AT57968 WP_015069931.1 NZ_CP013126:3357989-3358294 [Acidipropionibacterium acidipropionici]
MATASKAHDPITPGEILLTEFLEPMGITQYRLAQATGLSQTRISEIVRGKRAITTDTAPRLSKALGVDDRFWINIQTDYD
LEVERDLHADELAKVTTLVAS

Nucleotide

• Length: 306 bp

>AT57968 NZ_CP013126:3357989-3358294 [Acidipropionibacterium acidipropionici]
ATGGCGACAGCATCGAAGGCACACGACCCGATCACTCCCGGCGAGATCCTGCTGACTGAGTTTCTTGAGCCGATGGGCAT
CACGCAGTACCGCCTCGCCCAGGCCACTGGACTCTCCCAGACCCGGATCAGCGAGATCGTGCGCGGCAAGCGCGCCATCA
CCACCGATACCGCCCCCCGGCTGTCCAAGGCCCTCGGGGTCGACGACCGCTTCTGGATCAACATCCAGACCGACTACGAC
CTCGAGGTCGAGCGAGACCTGCACGCCGACGAACTGGCCAAGGTGACCACCCTGGTCGCGAGCTGA