Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3357732..3358294 Replicon chromosome
Accession NZ_CP013126
Organism Acidipropionibacterium acidipropionici strain CGMCC 1.2230

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ASQ49_RS15190 Protein ID WP_076692624.1
Coordinates 3357732..3357965 (+) Length 78 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag ASQ49_RS15195 Protein ID WP_015069931.1
Coordinates 3357989..3358294 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASQ49_RS15170 3353157..3354290 - 1134 WP_015069935.1 glycosyltransferase -
ASQ49_RS15175 3354295..3354621 - 327 WP_148279616.1 RDD family protein -
ASQ49_RS15180 3354753..3356042 - 1290 WP_015069933.1 hypothetical protein -
ASQ49_RS15185 3356255..3357676 + 1422 WP_015069932.1 type I glutamate--ammonia ligase -
ASQ49_RS15190 3357732..3357965 + 234 WP_076692624.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASQ49_RS15195 3357989..3358294 + 306 WP_015069931.1 HigA family addiction module antidote protein Antitoxin
ASQ49_RS15205 3358896..3359912 - 1017 WP_015069930.1 YdcF family protein -
ASQ49_RS15210 3360037..3360855 + 819 WP_028701670.1 Nif3-like dinuclear metal center hexameric protein -
ASQ49_RS15215 3360863..3362155 + 1293 WP_076692623.1 threonine/serine exporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(19-77)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8578.58 Da        Isoelectric Point: 6.6970

>T57968 WP_076692624.1 NZ_CP013126:3357732-3357965 [Acidipropionibacterium acidipropionici]
IIRPCCQHFTNGSTGGLVRLLNAASELNSPRVPPGNRLEKLVGGRDGQHSIRINDQYRICFVWTDNGADDVEITDYH

Download         Length: 234 bp

>T57968 NZ_CP013126:3357732-3357965 [Acidipropionibacterium acidipropionici]
ATCATCCGCCCGTGCTGCCAGCACTTCACCAACGGCAGCACGGGCGGACTCGTTCGCCTCCTCAACGCGGCCTCAGAACT
GAACAGCCCTCGGGTGCCGCCGGGAAATCGCTTGGAGAAGCTGGTCGGCGGCCGCGACGGCCAGCACTCCATCCGCATCA
ACGACCAGTACCGAATCTGCTTCGTGTGGACCGACAACGGAGCAGACGACGTCGAGATCACCGACTATCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11168.69 Da        Isoelectric Point: 4.8182

>AT57968 WP_015069931.1 NZ_CP013126:3357989-3358294 [Acidipropionibacterium acidipropionici]
MATASKAHDPITPGEILLTEFLEPMGITQYRLAQATGLSQTRISEIVRGKRAITTDTAPRLSKALGVDDRFWINIQTDYD
LEVERDLHADELAKVTTLVAS

Download         Length: 306 bp

>AT57968 NZ_CP013126:3357989-3358294 [Acidipropionibacterium acidipropionici]
ATGGCGACAGCATCGAAGGCACACGACCCGATCACTCCCGGCGAGATCCTGCTGACTGAGTTTCTTGAGCCGATGGGCAT
CACGCAGTACCGCCTCGCCCAGGCCACTGGACTCTCCCAGACCCGGATCAGCGAGATCGTGCGCGGCAAGCGCGCCATCA
CCACCGATACCGCCCCCCGGCTGTCCAAGGCCCTCGGGGTCGACGACCGCTTCTGGATCAACATCCAGACCGACTACGAC
CTCGAGGTCGAGCGAGACCTGCACGCCGACGAACTGGCCAAGGTGACCACCCTGGTCGCGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References