Detailed information of TA system TA057964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1051884..1052542
• Replicon: chromosome
• Accession: NZ_CP013126
• Organism: Acidipropionibacterium acidipropionici strain CGMCC 1.2230

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: K7RJ67
• Locus tag: ASQ49_RS04675
• Protein ID: WP_015068846.1
• Coordinates: 1051884..1052234 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: -
• Locus tag: ASQ49_RS04680
• Protein ID: WP_198027853.1
• Coordinates: 1052231..1052542 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASQ49_RS04650	1047754..1048836	+	1083	WP_148279593.1	ABC transporter substrate-binding protein	-
ASQ49_RS04655	1048833..1049897	+	1065	WP_051281928.1	iron chelate uptake ABC transporter family permease subunit	-
ASQ49_RS04660	1049894..1050703	+	810	WP_015068849.1	ABC transporter ATP-binding protein	-
ASQ49_RS04665	1050690..1051397	+	708	WP_015068848.1	(2Fe-2S) ferredoxin domain-containing protein	-
ASQ49_RS04670	1051506..1051703	-	198	WP_015068847.1	hypothetical protein	-
ASQ49_RS04675	1051884..1052234	+	351	WP_015068846.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ASQ49_RS04680	1052231..1052542	+	312	WP_198027853.1	helix-turn-helix domain-containing protein	Antitoxin
ASQ49_RS04685	1052708..1053361	+	654	WP_015068844.1	hypothetical protein	-
ASQ49_RS04690	1053904..1054578	+	675	WP_205628038.1	hypothetical protein	-
ASQ49_RS04695	1054581..1055837	-	1257	WP_051143434.1	IS256 family transposase	-
ASQ49_RS04700	1055965..1057389	+	1425	WP_160165414.1	PKD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (11-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13220.22 Da
• Isoelectric Point: 10.2579

>T57964 WP_015068846.1 NZ_CP013126:1051884-1052234 [Acidipropionibacterium acidipropionici]
MWSADLTLIADWLAGLDEGSQVQVVAAIELLKSIGPQLGRPLVDTVKASRHKNMKELRPGSSGRTELRILFAFDPRRKAI
LLIAGDKSNDWDRWYRRNIPLADDLFDEHLRALRRS

Nucleotide

• Length: 351 bp

>T57964 NZ_CP013126:1051884-1052234 [Acidipropionibacterium acidipropionici]
ATGTGGAGCGCCGACCTCACACTCATCGCCGACTGGCTTGCCGGGCTGGACGAGGGATCACAGGTTCAGGTCGTCGCCGC
CATAGAACTGTTGAAGAGCATCGGTCCTCAACTCGGTCGCCCTCTCGTCGACACTGTCAAAGCATCACGGCACAAGAACA
TGAAGGAACTCCGACCAGGCTCATCAGGCCGAACCGAGCTGCGCATCCTGTTCGCCTTCGATCCGAGACGCAAGGCGATC
CTGCTCATCGCCGGCGACAAGAGCAATGACTGGGATCGGTGGTACCGACGCAACATCCCCCTCGCCGACGACCTGTTCGA
CGAACACCTACGAGCACTGAGAAGGTCATGA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11484.21 Da
• Isoelectric Point: 5.7484

>AT57964 WP_198027853.1 NZ_CP013126:1052231-1052542 [Acidipropionibacterium acidipropionici]
MIMGLSLEEFLAEHPVDRDQVEAAKAEMLARVRAYRLRELREAAHLTQAQVAEKIGVSQRQVSKIETGDLNNSKLITVRK
YMEAVGGDLAVEFVSGDMRVQVA

Nucleotide

• Length: 312 bp

>AT57964 NZ_CP013126:1052231-1052542 [Acidipropionibacterium acidipropionici]
ATGATCATGGGACTGTCCTTGGAAGAGTTTCTCGCTGAACACCCCGTGGACCGCGACCAGGTCGAGGCTGCCAAGGCCGA
GATGCTGGCTCGGGTCCGCGCCTACCGGCTCCGTGAACTGCGCGAGGCCGCCCACCTCACTCAGGCCCAGGTGGCCGAGA
AGATCGGAGTCTCCCAGCGCCAGGTTTCCAAGATCGAGACCGGCGACCTCAACAACTCCAAGCTCATCACCGTACGCAAG
TACATGGAGGCTGTCGGTGGCGACCTGGCCGTCGAGTTCGTCTCCGGTGACATGCGCGTCCAAGTGGCGTGA

Structures

Toxin

• AlphaFold DB: K7RJ67