Detailed information of TA system TA057953

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2131087..2131677
• Replicon: chromosome
• Accession: NZ_CP013119
• Organism: Alcaligenes faecalis strain ZD02

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0A2N9E1
• Locus tag: UZ73_RS09650
• Protein ID: WP_035268575.1
• Coordinates: 2131087..2131383 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: UZ73_RS09655
• Protein ID: WP_042484646.1
• Coordinates: 2131390..2131677 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
UZ73_RS09635	2126879..2127775	-	897	WP_045930571.1	MurR/RpiR family transcriptional regulator	-
UZ73_RS09640	2127932..2128210	-	279	WP_045930570.1	acylphosphatase	-
UZ73_RS09645	2128388..2130952	+	2565	WP_109089926.1	EAL domain-containing protein	-
UZ73_RS09650	2131087..2131383	+	297	WP_035268575.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
UZ73_RS09655	2131390..2131677	+	288	WP_042484646.1	HigA family addiction module antidote protein	Antitoxin
UZ73_RS09660	2131788..2133155	-	1368	WP_045930569.1	DNA recombination protein RmuC	-
UZ73_RS09665	2133434..2134444	+	1011	WP_045930568.1	acyltransferase family protein	-
UZ73_RS09670	2134642..2135889	-	1248	WP_045930567.1	D-amino acid dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-98)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11108.48 Da
• Isoelectric Point: 9.3459

>T57953 WP_035268575.1 NZ_CP013119:2131087-2131383 [Alcaligenes faecalis]
MIKSFRHKGLQAYFETGSKSGIQAKHAVRLQIQLTALHSATQAEDMNAPGWKLHKLSGKNPKGQSVQDHYTISVSGNWRL
TFYFEGEDAVLVDYQDYH

Nucleotide

• Length: 297 bp

>T57953 NZ_CP013119:2131087-2131383 [Alcaligenes faecalis]
ATGATTAAGAGCTTCCGACACAAGGGTCTTCAGGCTTACTTTGAAACCGGCTCCAAATCCGGCATTCAAGCCAAGCATGC
TGTTCGCCTTCAGATTCAGTTAACGGCCCTGCACTCTGCTACTCAAGCGGAAGATATGAACGCCCCCGGATGGAAGCTCC
ACAAGTTATCTGGCAAAAACCCCAAAGGCCAATCTGTACAAGATCACTACACAATATCGGTTAGCGGAAACTGGCGTCTA
ACCTTTTACTTTGAAGGCGAAGACGCTGTTTTGGTGGACTACCAGGACTATCACTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10430.96 Da
• Isoelectric Point: 9.8929

>AT57953 WP_042484646.1 NZ_CP013119:2131390-2131677 [Alcaligenes faecalis]
IMRMHNPSHPGPVLREYLGELSVTEAASRLGVTRAALSRILNGSAGISADMALRLRDALGTSAEMWINMQSHYDLWQAEQ
KPRPKVVSFHGPAHA

Nucleotide

• Length: 288 bp

>AT57953 NZ_CP013119:2131390-2131677 [Alcaligenes faecalis]
ATTATGCGTATGCACAACCCATCCCACCCCGGCCCAGTCTTGCGGGAATACTTGGGCGAACTCAGTGTCACTGAGGCGGC
ATCCCGCCTTGGCGTAACGCGTGCAGCCTTATCGCGCATTCTCAATGGTTCTGCCGGTATTTCGGCAGACATGGCCTTAC
GCCTGCGCGACGCCCTTGGAACCAGTGCTGAAATGTGGATCAACATGCAGTCCCACTACGATCTTTGGCAGGCAGAGCAA
AAGCCAAGGCCCAAAGTCGTGTCCTTTCATGGACCTGCTCATGCCTGA

Structures

Toxin

• AlphaFold DB: A0A0A2N9E1