Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 1809809..1810318 Replicon chromosome
Accession NZ_CP013119
Organism Alcaligenes faecalis strain ZD02

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2U2BLI0
Locus tag UZ73_RS08175 Protein ID WP_045930786.1
Coordinates 1809809..1810051 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2U2BLG9
Locus tag UZ73_RS08180 Protein ID WP_045930785.1
Coordinates 1810073..1810318 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UZ73_RS08155 1806053..1806433 + 381 WP_045930789.1 RNA-binding S4 domain-containing protein -
UZ73_RS08160 1806869..1808023 + 1155 WP_045930788.1 mandelate racemase/muconate lactonizing enzyme family protein -
UZ73_RS08165 1808054..1809028 + 975 WP_045930787.1 tripartite tricarboxylate transporter substrate binding protein -
UZ73_RS08170 1809144..1809785 + 642 WP_045931162.1 HD domain-containing protein -
UZ73_RS08175 1809809..1810051 - 243 WP_045930786.1 Txe/YoeB family addiction module toxin Toxin
UZ73_RS08180 1810073..1810318 - 246 WP_045930785.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
UZ73_RS08185 1810433..1810807 - 375 WP_045930784.1 nucleotide pyrophosphohydrolase -
UZ73_RS08190 1810878..1811339 - 462 WP_045930783.1 YaiI/YqxD family protein -
UZ73_RS08195 1811343..1811609 - 267 WP_045930782.1 hypothetical protein -
UZ73_RS08200 1811971..1812252 - 282 WP_009463196.1 peptidylprolyl isomerase -
UZ73_RS08205 1812349..1813056 - 708 WP_045930781.1 TerC family protein -
UZ73_RS08210 1813510..1814016 + 507 WP_045930780.1 RNA polymerase sigma factor -
UZ73_RS08215 1814006..1815001 + 996 WP_045930779.1 FecR family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(19-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-70)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9278.89 Da        Isoelectric Point: 10.0957

>T57952 WP_045930786.1 NZ_CP013119:c1810051-1809809 [Alcaligenes faecalis]
MRHLKIDAKKVAAAGFKPKVQSLLAVLEIDPFQNPPPYEKLVGDLSGAYSRRINIQHRLVYEVLIPEHTVRVLRMWSHYE

Download         Length: 243 bp

>T57952 NZ_CP013119:c1810051-1809809 [Alcaligenes faecalis]
ATGCGGCACTTAAAGATAGATGCAAAAAAGGTGGCGGCAGCCGGGTTCAAACCTAAAGTGCAATCGTTACTCGCCGTGCT
AGAGATTGATCCATTCCAGAATCCCCCACCTTACGAGAAGTTGGTGGGGGATTTATCAGGGGCTTACTCTCGTCGTATCA
ATATTCAGCACAGACTTGTTTATGAGGTGCTGATTCCGGAGCATACCGTCCGAGTGCTGCGGATGTGGTCGCATTACGAA
TAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9010.09 Da        Isoelectric Point: 4.1948

>AT57952 WP_045930785.1 NZ_CP013119:c1810318-1810073 [Alcaligenes faecalis]
MTTTLTATEARANLYRLIDQTAESHQPIRIAGKRSSAVLISEADWEAIQETLYLSSIPGMRESIKEGMAEPLEDSATELD
W

Download         Length: 246 bp

>AT57952 NZ_CP013119:c1810318-1810073 [Alcaligenes faecalis]
ATGACGACTACTCTGACTGCGACTGAGGCACGCGCTAATCTTTATCGCCTCATTGATCAAACGGCTGAATCCCATCAGCC
TATTCGTATTGCGGGTAAGCGAAGTAGTGCCGTTCTTATATCGGAAGCAGATTGGGAAGCCATTCAAGAGACCTTGTACT
TGAGCTCCATCCCCGGGATGCGTGAGTCCATCAAAGAGGGTATGGCCGAACCGTTAGAAGATAGCGCGACGGAGCTTGAC
TGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U2BLI0

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2BLG9

References