Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5464364..5464959 Replicon chromosome
Accession NZ_CP013113
Organism Pseudomonas aeruginosa strain Paer4_119

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AQ622_RS25965 Protein ID WP_071538299.1
Coordinates 5464681..5464959 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AQ622_RS25960 Protein ID WP_003123432.1
Coordinates 5464364..5464669 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ622_RS25945 5459384..5462380 - 2997 WP_039843332.1 ATP-binding protein -
AQ622_RS25950 5462397..5462843 - 447 WP_052271067.1 DNA mismatch endonuclease Vsr -
AQ622_RS25955 5462850..5463875 - 1026 WP_052271065.1 DNA cytosine methyltransferase -
AQ622_RS25960 5464364..5464669 - 306 WP_003123432.1 HigA family addiction module antidote protein Antitoxin
AQ622_RS25965 5464681..5464959 - 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AQ622_RS25975 5465288..5467516 + 2229 WP_003113525.1 TonB-dependent receptor -
AQ622_RS25980 5467586..5468233 - 648 WP_003095021.1 carbonate dehydratase -
AQ622_RS25985 5468295..5469533 - 1239 WP_003123433.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T57946 WP_071538299.1 NZ_CP013113:c5464959-5464681 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T57946 NZ_CP013113:c5464959-5464681 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATGGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT57946 WP_003123432.1 NZ_CP013113:c5464669-5464364 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp

>AT57946 NZ_CP013113:c5464669-5464364 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References