Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 2013074..2013742 Replicon chromosome
Accession NZ_CP013103
Organism Paraburkholderia caribensis strain MWAP64

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AN416_RS25075 Protein ID WP_060605493.1
Coordinates 2013074..2013415 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AN416_RS25080 Protein ID WP_060605496.1
Coordinates 2013431..2013742 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN416_RS25055 2008694..2009671 + 978 WP_054933738.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -
AN416_RS25060 2009710..2010714 + 1005 WP_060605483.1 alpha-ketoacid dehydrogenase subunit beta -
AN416_RS25065 2010730..2011842 + 1113 WP_060605486.1 acetoin dehydrogenase dihydrolipoyllysine-residue acetyltransferase subunit -
AN416_RS25070 2011845..2012819 + 975 WP_060605490.1 lipoyl synthase -
AN416_RS25075 2013074..2013415 + 342 WP_060605493.1 hypothetical protein Toxin
AN416_RS25080 2013431..2013742 + 312 WP_060605496.1 helix-turn-helix domain-containing protein Antitoxin
AN416_RS25085 2013837..2015303 - 1467 WP_054933743.1 NAD-dependent succinate-semialdehyde dehydrogenase -
AN416_RS41370 2015331..2015540 + 210 WP_148654612.1 hypothetical protein -
AN416_RS25090 2016212..2017495 - 1284 WP_054933746.1 4-aminobutyrate--2-oxoglutarate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13194.11 Da        Isoelectric Point: 9.6373

>T57913 WP_060605493.1 NZ_CP013103:2013074-2013415 [Paraburkholderia caribensis]
VAATFVELGPFRRWRDDYLTDDEYRALQIVLMQNPEAGDVIRGTGGLRKLRFGDARRGKGKRGGLRVIYYYWVKGPEFWM
FTLYDKDEAEDLSSKERGVLSEMLREVIKLANR

Download         Length: 342 bp

>T57913 NZ_CP013103:2013074-2013415 [Paraburkholderia caribensis]
GTGGCGGCGACTTTCGTCGAGCTAGGCCCATTTCGCCGGTGGCGGGACGACTATCTGACGGACGACGAATATCGCGCGCT
TCAGATTGTGCTGATGCAGAACCCGGAAGCAGGGGATGTCATCAGGGGAACGGGTGGGCTGCGCAAACTCCGTTTCGGCG
ACGCACGGCGCGGGAAGGGAAAGCGCGGCGGGCTCAGGGTGATCTACTACTACTGGGTAAAGGGCCCCGAGTTCTGGATG
TTCACGCTGTACGACAAGGACGAAGCTGAAGACCTGTCGTCGAAGGAACGAGGGGTTCTCTCCGAGATGCTGAGAGAAGT
CATCAAGCTTGCGAATCGATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11827.65 Da        Isoelectric Point: 9.7238

>AT57913 WP_060605496.1 NZ_CP013103:2013431-2013742 [Paraburkholderia caribensis]
MKRNLLAELTEGLEELKSAHEGKTTLHKVKVEIRDKLEVTAEEIRAVRESINASQAVMARRLRVNERTYQNWEQGRAKPN
AQAAVLIKLVEKHPETIQMLETL

Download         Length: 312 bp

>AT57913 NZ_CP013103:2013431-2013742 [Paraburkholderia caribensis]
ATGAAACGGAATCTGTTAGCCGAATTGACGGAAGGGCTCGAAGAACTCAAGTCCGCTCACGAAGGCAAGACCACACTTCA
CAAGGTCAAGGTTGAGATTCGTGACAAGCTGGAAGTAACGGCCGAGGAGATCCGTGCCGTCCGCGAATCCATCAACGCGT
CACAGGCGGTCATGGCACGCCGTCTGCGCGTGAACGAGCGGACGTACCAGAATTGGGAGCAAGGGAGGGCGAAACCGAAC
GCTCAGGCTGCCGTGCTGATCAAGCTGGTTGAAAAGCATCCTGAGACGATCCAGATGCTCGAAACCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References