Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 172934..173539 Replicon plasmid C
Accession NZ_CP013054
Organism Sinorhizobium americanum CCGM7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SAMCCGM7_RS22380 Protein ID WP_072597337.1
Coordinates 173261..173539 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SAMCCGM7_RS22375 Protein ID WP_037385788.1
Coordinates 172934..173233 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAMCCGM7_RS22355 168615..169451 + 837 WP_037381707.1 ABC transporter permease -
SAMCCGM7_RS22360 169448..170542 + 1095 WP_037381705.1 ABC transporter ATP-binding protein -
SAMCCGM7_RS22365 170608..171651 + 1044 WP_037381703.1 GlxA family transcriptional regulator -
SAMCCGM7_RS22370 171791..172888 + 1098 WP_037390752.1 IS1595 family transposase -
SAMCCGM7_RS22375 172934..173233 - 300 WP_037385788.1 HigA family addiction module antidote protein Antitoxin
SAMCCGM7_RS22380 173261..173539 - 279 WP_072597337.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SAMCCGM7_RS22385 174129..175198 - 1070 Protein_160 divalent metal cation transporter -
SAMCCGM7_RS33805 175353..175769 + 417 WP_052035542.1 hypothetical protein -
SAMCCGM7_RS22395 176194..176570 + 377 Protein_162 hypothetical protein -
SAMCCGM7_RS22400 176875..178134 - 1260 WP_037385781.1 PHB depolymerase family esterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - katA / htpB 1..2249899 2249899
- flank IS/Tn - - 171791..172888 1097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10259.60 Da        Isoelectric Point: 8.0442

>T57847 WP_072597337.1 NZ_CP013054:c173539-173261 [Sinorhizobium americanum CCGM7]
IRSFKDAKTEAVARGKAPKGFPSDVVRSAVRKLTILNSAAALDDLRSPPGNRLEALKGDREGQHSIRINDQWRICFVWTD
AGIEDVEIVDYH

Download         Length: 279 bp

>T57847 NZ_CP013054:c173539-173261 [Sinorhizobium americanum CCGM7]
ATCAGGTCATTCAAGGACGCCAAAACCGAAGCCGTTGCGCGCGGCAAAGCACCAAAAGGCTTCCCTTCAGACGTCGTGAG
GTCGGCCGTTCGTAAATTGACGATCCTGAACAGTGCTGCCGCTCTCGATGACCTGCGATCCCCTCCGGGAAATCGACTTG
AAGCTCTTAAGGGCGATAGAGAAGGCCAACATTCGATCCGGATCAATGATCAGTGGCGCATATGCTTCGTATGGACAGAC
GCCGGTATCGAAGACGTCGAAATAGTTGACTACCATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11296.13 Da        Isoelectric Point: 6.2263

>AT57847 WP_037385788.1 NZ_CP013054:c173233-172934 [Sinorhizobium americanum CCGM7]
MTHILPPVHPGEILREEYLLPLNMSAGALAKKLNVPRTRIERIAAEQTPITTDTALRLAKYFRTTPEFWMNMQTSFNLKT
EEIALHRELELIPEIDGAA

Download         Length: 300 bp

>AT57847 NZ_CP013054:c173233-172934 [Sinorhizobium americanum CCGM7]
ATGACCCATATCCTTCCGCCGGTCCATCCGGGCGAAATCCTCCGCGAGGAGTACCTACTTCCTCTCAACATGAGTGCCGG
TGCACTGGCGAAAAAGCTCAATGTTCCCCGCACCCGCATCGAACGTATAGCGGCGGAGCAAACACCGATAACGACGGATA
CCGCTCTGCGCCTCGCCAAATATTTCCGCACAACGCCGGAATTTTGGATGAACATGCAGACCAGCTTCAACCTCAAGACA
GAGGAAATAGCACTTCATCGCGAACTGGAGTTGATCCCGGAAATCGATGGAGCCGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References