Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4878571..4879301 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name higB Uniprot ID A0A0P0QJB7
Locus tag AR325_RS23380 Protein ID WP_060560355.1
Coordinates 4878571..4878882 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AR325_RS23385 Protein ID WP_033632013.1
Coordinates 4878879..4879301 (+) Length 141 a.a.

Genomic Context

AR325_RS23350AR325_RS23355AR325_RS23360AR325_RS23365AR325_RS23370AR325_RS23375AR325_RS23380AR325_RS23385AR325_RS23390AR325_RS23395AR325_RS23400
Location: 4873898..4874623 (726 bp)
Type: Others
Protein ID: WP_004937040.1
Location: 4874676..4876109 (1434 bp)
Type: Others
Protein ID: WP_021505109.1
Location: 4876133..4876420 (288 bp)
Type: Others
Protein ID: WP_004937038.1
Location: 4876576..4877037 (462 bp)
Type: Others
Protein ID: WP_016930212.1
Location: 4877165..4878019 (855 bp)
Type: Others
Protein ID: WP_015379177.1
Location: 4878016..4878288 (273 bp)
Type: Others
Protein ID: WP_004937034.1
Location: 4878571..4878882 (312 bp)
Type: Toxin
Protein ID: WP_060560355.1
Location: 4878879..4879301 (423 bp)
Type: Antitoxin
Protein ID: WP_033632013.1
Location: 4879305..4881221 (1917 bp)
Type: Others
Protein ID: WP_015379179.1
Location: 4881273..4882487 (1215 bp)
Type: Others
Protein ID: WP_033632011.1
Location: 4882575..4883315 (741 bp)
Type: Others
Protein ID: WP_033648993.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AR325_RS233504873898..4874623+726WP_004937040.1LPS export ABC transporter ATP-binding protein-
AR325_RS233554874676..4876109+1434WP_021505109.1RNA polymerase factor sigma-54-
AR325_RS233604876133..4876420+288WP_004937038.1ribosome hibernation promoting factor-
AR325_RS233654876576..4877037+462WP_016930212.1PTS IIA-like nitrogen regulatory protein PtsN-
AR325_RS233704877165..4878019+855WP_015379177.1RNase adapter RapZ-
AR325_RS233754878016..4878288+273WP_004937034.1PTS phosphocarrier protein NPr-
AR325_RS233804878571..4878882+312WP_060560355.1type II toxin-antitoxin system HigB family toxinToxin
AR325_RS233854878879..4879301+423WP_033632013.1helix-turn-helix domain-containing proteinAntitoxin
AR325_RS233904879305..4881221-1917WP_015379179.1BglG family transcription antiterminator-
AR325_RS233954881273..4882487-1215WP_033632011.1lactonase family protein-
AR325_RS234004882575..4883315-741WP_033648993.1KDGP aldolase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12331.22 Da        Isoelectric Point: 10.0957

>T57840 WP_060560355.1 NZ_CP013046:4878571-4878882 [Serratia marcescens]
MHIISREPFNNATKQYPNEATALEAIYKALRRVEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

>T57840 NZ_CP013046:4878571-4878882 [Serratia marcescens]
ATGCATATCATTTCCAGGGAACCGTTCAATAACGCAACGAAACAATATCCCAATGAAGCCACTGCTCTCGAGGCCATTTA
TAAAGCGTTGCGACGGGTCGAGTTCCGCACGCCGGACGAGTTAAAAGCGCTTTTTCCTTCGCTCGATCGTATGAAATACA
AAGAGAAATGGTGGGTCATTGACGTCGGCGGCAACCACCTGCGGATCTTGTTCTTTGCCAGCTTCGAGACACAGAAAGTC
TTCATAAAGCATATCGTTAGCCACGCCGAATACGACAAGCTGATGCAGCACTATCGAAGGAGTTCATCATGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15833.20 Da        Isoelectric Point: 5.2297

>AT57840 WP_033632013.1 NZ_CP013046:4878879-4879301 [Serratia marcescens]
MITDAIKAADALLRAVPLLQGSRAQQDYREALELVEYLLENDERHPLIDMLAKKIAEYEDNSAEFTAFNQRITQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp

>AT57840 NZ_CP013046:4878879-4879301 [Serratia marcescens]
ATGATTACAGATGCCATTAAGGCGGCCGATGCGCTACTGCGCGCCGTGCCCTTGTTGCAGGGCAGCCGCGCTCAGCAAGA
CTACCGGGAAGCGCTCGAATTGGTGGAATACCTGCTGGAAAACGATGAACGCCATCCGCTGATTGACATGTTGGCAAAAA
AAATCGCCGAATATGAAGACAACAGCGCCGAATTTACCGCATTCAACCAGCGTATAACCCAACTCCCGCAGGGGGTGGCC
GCGCTTCGCGTACTGATGGAACAGCACCAACTCAGCCAAAGTGATTTTGAACATGAGATCGGTAAAAAGTCGTTGGTTAA
CCAAATCCTGAACGGCAAAAGATCGCTGACCATTCCGCACATTATGGCGCTGGCCAAGCGTTTCAATCTGCCCCCGGCCC
TGTTCCTGCCGGAAGCGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0P0QJB7

Antitoxin

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Source
ID
Structure
No matching records found

References