57836

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4378690..4379342 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name higB Uniprot ID A0A0P0QIF7
Locus tag AR325_RS21120 Protein ID WP_060560142.1
Coordinates 4378690..4379034 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag AR325_RS21125 Protein ID WP_004931828.1
Coordinates 4379040..4379342 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS21110 4375032..4377290 - 2259 WP_060560141.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
AR325_RS21115 4377511..4378530 + 1020 WP_004931832.1 HTH-type transcriptional regulator GalR -
AR325_RS21120 4378690..4379034 + 345 WP_060560142.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AR325_RS21125 4379040..4379342 + 303 WP_004931828.1 helix-turn-helix transcriptional regulator Antitoxin
AR325_RS21130 4379370..4380632 - 1263 WP_060560144.1 diaminopimelate decarboxylase -
AR325_RS21135 4380766..4381689 + 924 WP_060560145.1 LysR family transcriptional regulator -
AR325_RS21140 4381717..4382625 - 909 WP_015378928.1 LysR family transcriptional regulator -
AR325_RS21145 4382734..4383618 + 885 WP_004931820.1 MBL fold metallo-hydrolase -
AR325_RS21150 4383693..4384340 + 648 WP_033632219.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13441.54 Da        Isoelectric Point: 10.4277

>T57836 WP_060560142.1 NZ_CP013046:4378690-4379034 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIYKLQTFGPQLARPHADTLHFSDAVRQLKELRIQYRGRPFRMFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T57836 NZ_CP013046:4378690-4379034 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTTGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTACAAATTGCAGACGTTCGGCCCGCAATTGGCGCGGCCGCATGCCGATACGCTGCATTTTTCCGACGCGGTCC
GACAGTTGAAGGAGCTGCGCATTCAATATCGCGGGCGCCCTTTCAGGATGTTTTTCGCCTTTGATCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT57836 WP_004931828.1 NZ_CP013046:4379040-4379342 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT57836 NZ_CP013046:4379040-4379342 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
GATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGTTGGCGGTTTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAGCTGTCATCGCTCAAACGCTATATCGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0QIF7

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References