Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3592760..3593420 Replicon chromosome
Accession NZ_CP013046
Organism Serratia marcescens strain B3R3

Toxin (Protein)


Gene name higB Uniprot ID A0A0P0QGN5
Locus tag AR325_RS17335 Protein ID WP_060559891.1
Coordinates 3593067..3593420 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2V4GQ69
Locus tag AR325_RS17330 Protein ID WP_033635213.1
Coordinates 3592760..3593062 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR325_RS17310 3588387..3589301 - 915 WP_048324303.1 branched-chain amino acid ABC transporter permease -
AR325_RS17315 3589425..3590543 - 1119 WP_033632602.1 branched-chain amino acid ABC transporter substrate-binding protein -
AR325_RS17325 3591126..3592334 - 1209 WP_033632601.1 aldose 1-epimerase family protein -
AR325_RS17330 3592760..3593062 - 303 WP_033635213.1 XRE family transcriptional regulator Antitoxin
AR325_RS17335 3593067..3593420 - 354 WP_060559891.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AR325_RS17340 3593858..3595153 + 1296 WP_033632599.1 MFS transporter -
AR325_RS17345 3595180..3595986 + 807 WP_060559892.1 substrate-binding domain-containing protein -
AR325_RS17350 3595961..3596860 - 900 WP_049278342.1 LysR family transcriptional regulator -
AR325_RS17355 3596964..3597329 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13508.46 Da        Isoelectric Point: 9.5163

>T57834 WP_060559891.1 NZ_CP013046:c3593420-3593067 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLRGKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGM
VLCAGNKAGNEKRFYDRMVQIADREFTNWLNTLNEKE

Download         Length: 354 bp

>T57834 NZ_CP013046:c3593420-3593067 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTCAGATCACTCAGCGATGCCGACCGGGCCTGCGTGCTTGC
TGCATTGATGGTCCTGCGGGGAAAAGGGCCCGGCTTGCCCAGACCCTATGCCGATACGGTTAAAGGCTCGCGTTACAGCA
ACATGAAAGAGCTGCGTATTCAGAGCCGTGGCGAACCGTTGCGGGCATTCTTCGCTTTCGATCCGTACCGTATTGGCATG
GTGCTTTGCGCGGGCAATAAAGCCGGTAATGAAAAGCGTTTTTACGATCGAATGGTGCAGATTGCCGATCGGGAATTCAC
GAACTGGCTGAACACATTAAACGAGAAGGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11079.94 Da        Isoelectric Point: 6.4738

>AT57834 WP_033635213.1 NZ_CP013046:c3593062-3592760 [Serratia marcescens]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT57834 NZ_CP013046:c3593062-3592760 [Serratia marcescens]
ATGGGCAGAACGTTGGAACAGCTTATTGCGGATGAAAAGCCCGAGGTCGTGGCCAAAGCGCAGGCGCTGGCGGCGGACAT
CATGCTGAACATTCACCTTGCCGAGCTGCGTGAAAAAGTACAGAAAACGCAGGTTGAAATGGCGCAGGCGCTAGGGATCA
GGCAGCCGACCGTCGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTTAAACGCTATGTTGAGGCGGCC
GGCGGCAAACTGCGCCTGGATGTCGAACTGCCGGACGGTTCGCACTACGAATTTGTGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0QGN5

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GQ69

References