Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2490323..2490545 Replicon chromosome
Accession NZ_CP013025
Organism Escherichia coli strain 2009C-3133

Toxin (Protein)


Gene name ldrD Uniprot ID A0A829L523
Locus tag MJ49_RS31750 Protein ID WP_000170738.1
Coordinates 2490438..2490545 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2490323..2490389 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ49_RS13240 2485764..2486666 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
MJ49_RS13245 2486677..2487660 + 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
MJ49_RS13250 2487657..2488661 + 1005 WP_000107036.1 dipeptide ABC transporter ATP-binding subunit DppF -
MJ49_RS13255 2488691..2489962 - 1272 WP_001318103.1 amino acid permease -
- 2490323..2490389 - 67 - - Antitoxin
MJ49_RS31750 2490438..2490545 + 108 WP_000170738.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
MJ49_RS29060 2490921..2491028 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
MJ49_RS32750 2491404..2491511 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
MJ49_RS32270 2491887..2491994 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
MJ49_RS13285 2492219..2492677 + 459 WP_000526135.1 IS200/IS605 family transposase -
MJ49_RS13290 2492792..2494471 - 1680 WP_001562264.1 cellulose biosynthesis protein BcsG -
MJ49_RS13295 2494468..2494659 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2492219..2492677 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3864.67 Da        Isoelectric Point: 9.0157

>T57728 WP_000170738.1 NZ_CP013025:2490438-2490545 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASLIVNWLNKRK

Download         Length: 108 bp

>T57728 NZ_CP013025:2490438-2490545 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATAGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT57728 NZ_CP013025:c2490389-2490323 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L523

Antitoxin

Download structure file

References