Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1154728..1155455 Replicon chromosome
Accession NZ_CP012999
Organism Enterobacter sp. E20

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NI40_RS05345 Protein ID WP_039264040.1
Coordinates 1155144..1155455 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NI40_RS05340 Protein ID WP_039264039.1
Coordinates 1154728..1155147 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NI40_RS05310 1150049..1152031 + 1983 WP_045142935.1 FUSC family protein -
NI40_RS05315 1152024..1152239 + 216 WP_039264034.1 DUF1656 domain-containing protein -
NI40_RS05320 1152236..1153099 + 864 WP_039264035.1 HlyD family secretion protein -
NI40_RS05325 1153116..1153541 - 426 WP_039264037.1 VOC family protein -
NI40_RS05330 1153543..1154136 - 594 WP_039264038.1 hypothetical protein -
NI40_RS05335 1154248..1154658 - 411 WP_039264103.1 hypothetical protein -
NI40_RS05340 1154728..1155147 - 420 WP_039264039.1 helix-turn-helix domain-containing protein Antitoxin
NI40_RS05345 1155144..1155455 - 312 WP_039264040.1 type II toxin-antitoxin system HigB family toxin Toxin
NI40_RS22500 1155850..1157397 - 1548 WP_071884814.1 hypothetical protein -
NI40_RS05350 1157650..1158105 - 456 WP_039264041.1 hypothetical protein -
NI40_RS22505 1158133..1158240 - 108 WP_157843315.1 ash family protein -
NI40_RS05355 1158545..1159429 - 885 WP_039264042.1 LysR family transcriptional regulator -
NI40_RS05360 1159539..1160174 + 636 WP_039264044.1 glutathione transferase GstA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12417.25 Da        Isoelectric Point: 10.0936

>T57671 WP_039264040.1 NZ_CP012999:c1155455-1155144 [Enterobacter sp. E20]
MHVVSRAPFDAATRQFPNQAQALDDLYRVLKKEHYPSPDDMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKI
FIKHISTHAEYDKLTDLYRRTKE

Download         Length: 312 bp

>T57671 NZ_CP012999:c1155455-1155144 [Enterobacter sp. E20]
ATGCACGTCGTCTCAAGAGCGCCTTTCGACGCGGCTACCAGACAATTTCCTAATCAAGCACAAGCCCTGGACGATCTTTA
CCGGGTACTAAAAAAGGAGCATTACCCGTCACCGGACGATATGCGAAAACGCTTCCCCAGCCTGGACAGGATGAAGTACC
GGGAGAAATGGTGGGTCATTGATGTGGGTGGCGGGCATTTAAGAGTGATGTTTTTTGCTGATTTTGAGCGAGGAAAGATT
TTCATCAAACACATCAGCACACACGCAGAATATGACAAGCTCACGGACCTCTACCGGAGAACGAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15500.62 Da        Isoelectric Point: 5.2145

>AT57671 WP_039264039.1 NZ_CP012999:c1155147-1154728 [Enterobacter sp. E20]
MNYATAIKAANDLTNALPFLGSSPSRHDYEDALALVEYLVEHEPDSPLVDMLTAKIDKYENESPEFAEFNARVARIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGK

Download         Length: 420 bp

>AT57671 NZ_CP012999:c1155147-1154728 [Enterobacter sp. E20]
ATGAATTATGCAACAGCCATCAAAGCGGCAAACGATCTGACAAACGCGCTCCCTTTCCTGGGCTCAAGCCCGTCGCGGCA
TGATTACGAGGATGCGCTGGCGTTGGTGGAGTATCTGGTCGAACACGAACCCGATAGCCCGCTGGTAGATATGCTCACCG
CAAAAATCGATAAGTACGAAAACGAGTCTCCGGAGTTTGCGGAATTTAACGCGCGTGTTGCCCGCATTCCGTCAGGCGTT
GCGTTATTGCGAACGCTGATGGATCAATACCAACTCACTCAGAGCGACTTCGAGAACGAAATTGGCAAGAAGTCTCTGGT
GAGTCGAATCCTTAATGGACAGCGCACGTTAACGCTGGATCATATGCGTGCGCTGGCGAAGCGTTTTGGTTTGCCGGTGA
GTGCGTTTGTCGGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References