Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 884410..885025 | Replicon | chromosome |
| Accession | NZ_CP012997 | ||
| Organism | Vibrio cholerae strain 2012Env-9 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | NH62_RS04125 | Protein ID | WP_001162670.1 |
| Coordinates | 884738..885025 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NH62_RS04120 | Protein ID | WP_001232701.1 |
| Coordinates | 884410..884727 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NH62_RS04095 | 879559..880434 | - | 876 | WP_000259044.1 | hypothetical protein | - |
| NH62_RS04105 | 880881..881357 | - | 477 | WP_148661834.1 | hypothetical protein | - |
| NH62_RS04110 | 881414..882244 | - | 831 | WP_000056616.1 | abortive infection family protein | - |
| NH62_RS04115 | 882449..883189 | - | 741 | WP_000469836.1 | PhzF family phenazine biosynthesis protein | - |
| NH62_RS20375 | 883413..883451 | - | 39 | WP_106019119.1 | hypothetical protein | - |
| NH62_RS20380 | 883467..883592 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
| NH62_RS19265 | 883938..884108 | - | 171 | WP_001882300.1 | DUF645 family protein | - |
| NH62_RS20385 | 884303..884413 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| NH62_RS04120 | 884410..884727 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| NH62_RS04125 | 884738..885025 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| NH62_RS19280 | 885292..885472 | - | 181 | Protein_815 | DUF645 family protein | - |
| NH62_RS19285 | 885897..886130 | - | 234 | Protein_816 | DUF3709 domain-containing protein | - |
| NH62_RS04130 | 886533..886751 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| NH62_RS04135 | 887061..887714 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| NH62_RS04140 | 887771..888280 | - | 510 | WP_000405986.1 | GNAT family N-acetyltransferase | - |
| NH62_RS04145 | 888522..888764 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| NH62_RS04150 | 888783..889100 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| NH62_RS19295 | 889115..889237 | - | 123 | WP_080033517.1 | DUF3265 domain-containing protein | - |
| NH62_RS04155 | 889259..889477 | - | 219 | WP_001209280.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 827256..947647 | 120391 | |
| - | inside | Integron | - | - | 828501..941266 | 112765 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T57665 WP_001162670.1 NZ_CP012997:c885025-884738 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T57665 NZ_CP012997:c885025-884738 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT57665 WP_001232701.1 NZ_CP012997:c884727-884410 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT57665 NZ_CP012997:c884727-884410 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|