Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3125768..3126414 Replicon chromosome
Accession NZ_CP012992
Organism Klebsiella pneumoniae strain KpN06

Toxin (Protein)


Gene name higB Uniprot ID A6TF46
Locus tag AQD73_RS15420 Protein ID WP_015959099.1
Coordinates 3125768..3126115 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag AQD73_RS15425 Protein ID WP_004174017.1
Coordinates 3126115..3126414 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQD73_RS15410 3121694..3123127 + 1434 WP_002920564.1 glycogen synthase GlgA -
AQD73_RS15415 3123145..3125592 + 2448 WP_002920561.1 glycogen phosphorylase -
AQD73_RS15420 3125768..3126115 + 348 WP_015959099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AQD73_RS15425 3126115..3126414 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
AQD73_RS15430 3126477..3127985 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
AQD73_RS15435 3128190..3128519 + 330 WP_009484088.1 thiosulfate sulfurtransferase GlpE -
AQD73_RS15440 3128570..3129400 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
AQD73_RS15445 3129450..3130208 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13519.49 Da        Isoelectric Point: 6.2327

>T57637 WP_015959099.1 NZ_CP012992:3125768-3126115 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMNTLADREFSQHLTKER

Download         Length: 348 bp

>T57637 NZ_CP012992:3125768-3126115 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGAATACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT57637 WP_004174017.1 NZ_CP012992:3126115-3126414 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT57637 NZ_CP012992:3126115-3126414 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TF46

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References