Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3191466..3192166 Replicon chromosome
Accession NZ_CP012982
Organism Burkholderia cepacia ATCC 25416 strain UCB 717

Toxin (Protein)


Gene name mqsR Uniprot ID A0A806V3J0
Locus tag APZ15_RS31520 Protein ID WP_027791640.1
Coordinates 3191870..3192166 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A806V1K0
Locus tag APZ15_RS31515 Protein ID WP_027791641.1
Coordinates 3191466..3191867 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ15_RS31495 3187105..3188457 - 1353 WP_027791645.1 LLM class flavin-dependent oxidoreductase -
APZ15_RS31500 3188465..3189514 - 1050 WP_027791644.1 LLM class flavin-dependent oxidoreductase -
APZ15_RS31505 3189578..3190531 - 954 WP_027791643.1 ABC transporter substrate-binding protein -
APZ15_RS31510 3190588..3191148 - 561 WP_027791642.1 GNAT family N-acetyltransferase -
APZ15_RS31515 3191466..3191867 - 402 WP_027791641.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
APZ15_RS31520 3191870..3192166 - 297 WP_027791640.1 type II toxin-antitoxin system MqsR family toxin Toxin
APZ15_RS31525 3192270..3193310 - 1041 WP_027791639.1 succinylglutamate desuccinylase/aspartoacylase family protein -
APZ15_RS31530 3193565..3193840 - 276 WP_027791638.1 hypothetical protein -
APZ15_RS31535 3194084..3195634 - 1551 WP_027791637.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11203.05 Da        Isoelectric Point: 8.0535

>T57604 WP_027791640.1 NZ_CP012982:c3192166-3191870 [Burkholderia cepacia ATCC 25416]
MEKRRPHCKLPLVKALVESGQVRLTASAVLGARQLGFTEREALDVVMSLTDLDFHKSMTTYADHTIWQDVYRPLTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T57604 NZ_CP012982:c3192166-3191870 [Burkholderia cepacia ATCC 25416]
ATGGAAAAGAGAAGGCCTCATTGCAAGCTGCCCCTCGTCAAGGCGCTGGTCGAATCCGGCCAGGTCCGGTTGACCGCGAG
CGCGGTACTCGGCGCGCGGCAGCTGGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGATGTCGCTGACCGACCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCGTTGACGGTGCGTGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14549.82 Da        Isoelectric Point: 8.8305

>AT57604 WP_027791641.1 NZ_CP012982:c3191867-3191466 [Burkholderia cepacia ATCC 25416]
MKCPACGAAKLVRDTRDIPYTYKGRSTVVRAVTGEFCPACGESVLDLDEATRLGEAISEFNKQVNATIVDPNYIAKVRKK
LKLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT57604 NZ_CP012982:c3191867-3191466 [Burkholderia cepacia ATCC 25416]
ATGAAGTGTCCTGCATGCGGTGCTGCGAAGCTCGTCCGCGACACGCGCGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTCCGCGCTGTCACCGGCGAGTTCTGCCCGGCCTGCGGGGAATCGGTGCTGGATCTCGACGAAGCGACCCGTCTCG
GCGAAGCGATCAGCGAGTTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAATTACATCGCGAAGGTGCGCAAGAAG
CTGAAGCTCGACCAGCGCGAGGCGGCCGAGCTTTTCGGCGGCGGCGTCAACGCGTTCTCCCGTTACGAAACAGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAACTGCTGAAGATCCTCGATCGTCATCCCGATCTGCTCGCCGAAGTCCGGGCCGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806V3J0

Antitoxin

Source ID Structure
AlphaFold DB A0A806V1K0

References