Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1965122..1965737 Replicon chromosome
Accession NZ_CP012982
Organism Burkholderia cepacia ATCC 25416 strain UCB 717

Toxin (Protein)


Gene name higB Uniprot ID A0A806VP16
Locus tag APZ15_RS26135 Protein ID WP_027789973.1
Coordinates 1965396..1965737 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A806UZQ0
Locus tag APZ15_RS26130 Protein ID WP_027789974.1
Coordinates 1965122..1965409 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ15_RS26100 1960665..1961444 - 780 WP_027789979.1 5'/3'-nucleotidase SurE -
APZ15_RS26105 1961763..1962071 - 309 WP_027789978.1 AzlD family protein -
APZ15_RS26110 1962064..1962798 - 735 WP_027789977.1 AzlC family ABC transporter permease -
APZ15_RS26115 1962925..1963383 + 459 WP_006749370.1 Lrp/AsnC family transcriptional regulator -
APZ15_RS26120 1963604..1964173 + 570 WP_027789976.1 hypothetical protein -
APZ15_RS26125 1964353..1965042 + 690 WP_027789975.1 YebB family permuted papain-like enzyme -
APZ15_RS26130 1965122..1965409 - 288 WP_027789974.1 helix-turn-helix transcriptional regulator Antitoxin
APZ15_RS26135 1965396..1965737 - 342 WP_027789973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APZ15_RS26140 1965953..1966585 - 633 WP_027789972.1 LysE family translocator -
APZ15_RS26145 1967015..1968652 + 1638 WP_027789971.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13112.25 Da        Isoelectric Point: 9.5171

>T57600 WP_027789973.1 NZ_CP012982:c1965737-1965396 [Burkholderia cepacia ATCC 25416]
MRTVADEIHFFSEQVEAGVFALPKTLIARFFALADRMEQYGPNPGEPHTRPMGDGLYEMRLKGLEDIARVFYCAVVNRRI
VMLHCYVKKTQKTPQKDLETARRRLKEIRDGNL

Download         Length: 342 bp

>T57600 NZ_CP012982:c1965737-1965396 [Burkholderia cepacia ATCC 25416]
ATGCGAACCGTCGCGGATGAAATCCATTTCTTCAGCGAGCAAGTCGAGGCTGGCGTATTTGCGTTGCCGAAAACGCTGAT
CGCCAGATTCTTCGCACTCGCTGACCGCATGGAGCAGTACGGCCCGAATCCGGGCGAACCTCACACCAGGCCGATGGGCG
ACGGGTTGTACGAAATGCGGTTGAAGGGCCTGGAAGATATCGCACGTGTGTTTTACTGCGCGGTCGTCAACCGGCGGATC
GTCATGCTTCACTGCTACGTGAAGAAGACGCAGAAAACGCCGCAGAAGGACCTGGAAACCGCGCGCCGCCGATTGAAGGA
GATTCGAGATGGCAACCTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10296.90 Da        Isoelectric Point: 9.6540

>AT57600 WP_027789974.1 NZ_CP012982:c1965409-1965122 [Burkholderia cepacia ATCC 25416]
MATYKALRERALADPTVCAEYDRLNREEFALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIDTLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT57600 NZ_CP012982:c1965409-1965122 [Burkholderia cepacia ATCC 25416]
ATGGCAACCTATAAGGCACTGCGCGAGCGCGCGTTGGCCGATCCGACGGTATGCGCCGAGTACGACCGGCTGAACCGCGA
GGAATTCGCGCTGCTCGACGCAATGCTGGCCGCCCGGCGAGCCGCCGGTCTTTCGCAAGCCGATGTGGCAGAGCGCATGG
GCACGAAGGCGCCTGCCGTCACGCGGCTCGAACGTGCGCTCGCGACAGGCCAGCACTCGCCGTCGATTGATACGCTGCGC
AAGTATGCGGCCGCATGCGGCAAGAAACTCGTGATCTCTTTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806VP16

Antitoxin

Source ID Structure
AlphaFold DB A0A806UZQ0

References