Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1926663..1927320 Replicon chromosome
Accession NZ_CP012982
Organism Burkholderia cepacia ATCC 25416 strain UCB 717

Toxin (Protein)


Gene name higB Uniprot ID A0A806V1Y2
Locus tag APZ15_RS25945 Protein ID WP_027790007.1
Coordinates 1926663..1926995 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S5CU29
Locus tag APZ15_RS25950 Protein ID WP_027790006.1
Coordinates 1926988..1927320 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APZ15_RS25930 1922576..1923718 + 1143 WP_027790010.1 branched-chain amino acid ABC transporter substrate-binding protein -
APZ15_RS25935 1923799..1924668 - 870 WP_027790009.1 mechanosensitive ion channel family protein -
APZ15_RS25940 1925009..1926373 + 1365 WP_027790008.1 M23 family metallopeptidase -
APZ15_RS25945 1926663..1926995 + 333 WP_027790007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
APZ15_RS25950 1926988..1927320 + 333 WP_027790006.1 helix-turn-helix domain-containing protein Antitoxin
APZ15_RS25955 1927507..1928352 - 846 WP_027790005.1 AraC family transcriptional regulator -
APZ15_RS25960 1928506..1929327 - 822 WP_027790004.1 fucose-binding lectin II -
APZ15_RS25965 1929452..1929841 - 390 WP_027790003.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1914489..1927320 12831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-105)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12948.12 Da        Isoelectric Point: 10.0669

>T57599 WP_027790007.1 NZ_CP012982:1926663-1926995 [Burkholderia cepacia ATCC 25416]
MKKWTILYYDERVKRDVFALPKGILAGYLRLIEAMEEHGADLRMPYSRAMGEGLFELRPRGREGIGRVFYCIRVGYELVV
LHSFVKKTQETPNDELQIARRRMKEVRNNG

Download         Length: 333 bp

>T57599 NZ_CP012982:1926663-1926995 [Burkholderia cepacia ATCC 25416]
ATGAAGAAGTGGACGATCCTGTACTACGACGAACGGGTAAAGCGTGATGTGTTCGCTTTGCCCAAGGGCATTCTGGCTGG
CTACCTCCGACTGATCGAGGCGATGGAAGAACACGGTGCGGATCTGCGGATGCCGTATTCGCGCGCGATGGGGGAAGGAT
TGTTTGAATTGCGCCCGCGAGGCCGTGAAGGCATCGGGCGTGTGTTCTATTGCATCCGGGTGGGATATGAACTCGTCGTC
CTGCATTCCTTCGTCAAGAAGACGCAGGAAACACCCAACGACGAGTTGCAAATCGCCCGCAGGCGAATGAAGGAGGTACG
TAACAATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11971.52 Da        Isoelectric Point: 8.0521

>AT57599 WP_027790006.1 NZ_CP012982:1926988-1927320 [Burkholderia cepacia ATCC 25416]
MAKARPAHTSEERYAPVRHTAEDTARLLTDPAIKAEYDALEEEFTALRALLDARKDAGLTQAQVAERMGTTTSAVSRLEA
SFSSEKHSPSFATLRKYAAACGKKLVISFA

Download         Length: 333 bp

>AT57599 NZ_CP012982:1926988-1927320 [Burkholderia cepacia ATCC 25416]
ATGGCTAAGGCTCGCCCCGCACATACAAGCGAGGAGCGGTATGCACCGGTCCGACACACTGCCGAAGACACCGCACGTCT
GCTCACCGATCCGGCCATCAAGGCGGAATACGATGCACTGGAAGAGGAGTTCACCGCGCTTCGTGCGTTGCTCGACGCGC
GCAAGGATGCGGGCCTGACTCAGGCTCAGGTCGCCGAACGAATGGGCACCACGACGTCGGCCGTATCGAGGCTCGAAGCT
TCGTTTTCGAGCGAGAAGCACTCGCCGTCGTTTGCGACGCTGCGCAAGTACGCCGCAGCGTGCGGCAAGAAGCTCGTCAT
TTCGTTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806V1Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5CU29

References