Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2368743..2368927 Replicon chromosome
Accession NZ_CP012979
Organism Staphylococcus aureus strain ST20130940

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SAST40_RS11865 Protein ID WP_000482647.1
Coordinates 2368820..2368927 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2368743..2368803 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST40_RS11840 2364197..2364364 - 168 WP_001792506.1 hypothetical protein -
SAST40_RS11850 2364595..2366328 - 1734 WP_000486496.1 ABC transporter ATP-binding protein/permease -
SAST40_RS11855 2366353..2368116 - 1764 WP_001064836.1 ABC transporter ATP-binding protein/permease -
- 2368743..2368803 + 61 - - Antitoxin
SAST40_RS11865 2368820..2368927 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SAST40_RS11870 2369061..2369447 - 387 WP_000779360.1 flippase GtxA -
SAST40_RS11875 2369705..2370847 + 1143 WP_001176863.1 glycerate kinase -
SAST40_RS11880 2370907..2371566 + 660 WP_000831295.1 hypothetical protein -
SAST40_RS11885 2371748..2372959 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAST40_RS11890 2373082..2373555 - 474 WP_062909965.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T57590 WP_000482647.1 NZ_CP012979:c2368927-2368820 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T57590 NZ_CP012979:c2368927-2368820 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT57590 NZ_CP012979:2368743-2368803 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References