Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2088119..2088381 Replicon chromosome
Accession NZ_CP012979
Organism Staphylococcus aureus strain ST20130940

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAST40_RS10360 Protein ID WP_001802298.1
Coordinates 2088277..2088381 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF2
Locus tag -
Coordinates 2088119..2088282 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST40_RS10340 2083135..2083455 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAST40_RS10345 2083457..2084437 + 981 WP_000019739.1 CDF family zinc efflux transporter CzrB -
SAST40_RS10350 2084703..2085794 + 1092 WP_000495672.1 hypothetical protein -
SAST40_RS10355 2085823..2087469 - 1647 WP_000277718.1 IS1182 family transposase -
- 2088119..2088282 + 164 - - Antitoxin
SAST40_RS10360 2088277..2088381 - 105 WP_001802298.1 hypothetical protein Toxin
SAST40_RS13965 2089061..2089219 + 159 WP_001792784.1 hypothetical protein -
SAST40_RS10365 2089878..2090735 - 858 WP_000370931.1 Cof-type HAD-IIB family hydrolase -
SAST40_RS10370 2090803..2091585 - 783 WP_000908174.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2085823..2087469 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T57587 WP_001802298.1 NZ_CP012979:c2088381-2088277 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T57587 NZ_CP012979:c2088381-2088277 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 164 bp

>AT57587 NZ_CP012979:2088119-2088282 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References