Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2423927..2424111 Replicon chromosome
Accession NZ_CP012976
Organism Staphylococcus aureus strain ST20130942

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag SAST42_RS12285 Protein ID WP_000482652.1
Coordinates 2424004..2424111 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2423927..2423987 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST42_RS12260 2419438..2419605 - 168 Protein_2323 hypothetical protein -
SAST42_RS12270 2419836..2421569 - 1734 WP_031918671.1 ABC transporter ATP-binding protein/permease -
SAST42_RS12275 2421594..2423357 - 1764 WP_001064809.1 ABC transporter ATP-binding protein/permease -
- 2423927..2423987 + 61 - - Antitoxin
SAST42_RS12285 2424004..2424111 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
SAST42_RS12290 2424245..2424631 - 387 WP_000779357.1 flippase GtxA -
SAST42_RS12295 2424899..2426041 + 1143 WP_001176863.1 glycerate kinase -
SAST42_RS12300 2426101..2426760 + 660 WP_000831298.1 membrane protein -
SAST42_RS12305 2426942..2428153 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAST42_RS12310 2428276..2428749 - 474 WP_000456484.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T57570 WP_000482652.1 NZ_CP012976:c2424111-2424004 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T57570 NZ_CP012976:c2424111-2424004 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT57570 NZ_CP012976:2423927-2423987 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References