Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2398552..2399069 Replicon chromosome
Accession NZ_CP012976
Organism Staphylococcus aureus strain ST20130942

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag SAST42_RS12135 Protein ID WP_000113262.1
Coordinates 2398552..2398818 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAST42_RS12140 Protein ID WP_000584499.1
Coordinates 2398818..2399069 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST42_RS12110 2393977..2394513 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
SAST42_RS12115 2394746..2395570 - 825 WP_000572040.1 formate/nitrite transporter family protein -
SAST42_RS12120 2395787..2395969 - 183 WP_000230294.1 hypothetical protein -
SAST42_RS12125 2396053..2396520 - 468 WP_000153344.1 SRPBCC domain-containing protein -
SAST42_RS12130 2396707..2398257 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAST42_RS14710 2398446..2398517 - 72 Protein_2298 hypothetical protein -
SAST42_RS12135 2398552..2398818 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
SAST42_RS12140 2398818..2399069 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAST42_RS12145 2399234..2399335 - 102 WP_001791744.1 hypothetical protein -
SAST42_RS12150 2399342..2399941 - 600 WP_000162813.1 DsbA family protein -
SAST42_RS12155 2399960..2400322 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAST42_RS12160 2400577..2401827 + 1251 WP_001012227.1 FemA/FemB family glycyltransferase FmhA -
SAST42_RS12165 2401924..2402655 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SAST42_RS12170 2402652..2403371 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T57569 WP_000113262.1 NZ_CP012976:c2398818-2398552 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T57569 NZ_CP012976:c2398818-2398552 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT57569 WP_000584499.1 NZ_CP012976:c2399069-2398818 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT57569 NZ_CP012976:c2399069-2398818 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References