Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2455505..2456028 Replicon chromosome
Accession NZ_CP012974
Organism Staphylococcus aureus strain ST20130943

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag SAST43_RS12435 Protein ID WP_000074045.1
Coordinates 2455505..2455771 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag SAST43_RS12440 Protein ID WP_000587619.1
Coordinates 2455771..2456028 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST43_RS12415 2450811..2451998 - 1188 WP_000026189.1 MFS transporter -
SAST43_RS12420 2452394..2453170 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
SAST43_RS12425 2453163..2453825 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
SAST43_RS12430 2454073..2455149 - 1077 WP_001076673.1 M42 family metallopeptidase -
SAST43_RS12435 2455505..2455771 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
SAST43_RS12440 2455771..2456028 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAST43_RS12450 2456388..2456843 + 456 WP_000732082.1 DUF1307 domain-containing protein -
SAST43_RS12455 2457011..2458588 - 1578 WP_000143502.1 FMN-binding glutamate synthase family protein -
SAST43_RS12460 2458783..2459532 + 750 WP_000072440.1 hypothetical protein -
SAST43_RS12465 2459770..2460963 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T57557 WP_000074045.1 NZ_CP012974:c2455771-2455505 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T57557 NZ_CP012974:c2455771-2455505 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT57557 WP_000587619.1 NZ_CP012974:c2456028-2455771 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT57557 NZ_CP012974:c2456028-2455771 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References