Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2398615..2399132 Replicon chromosome
Accession NZ_CP012974
Organism Staphylococcus aureus strain ST20130943

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag SAST43_RS12135 Protein ID WP_000113262.1
Coordinates 2398615..2398881 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAST43_RS12140 Protein ID WP_000584499.1
Coordinates 2398881..2399132 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST43_RS12110 2394040..2394576 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
SAST43_RS12115 2394809..2395633 - 825 WP_000572040.1 formate/nitrite transporter family protein -
SAST43_RS12120 2395850..2396032 - 183 WP_000230294.1 hypothetical protein -
SAST43_RS12125 2396116..2396583 - 468 WP_000153344.1 SRPBCC domain-containing protein -
SAST43_RS12130 2396770..2398320 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAST43_RS14710 2398509..2398580 - 72 Protein_2297 hypothetical protein -
SAST43_RS12135 2398615..2398881 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
SAST43_RS12140 2398881..2399132 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAST43_RS12145 2399297..2399398 - 102 WP_001791744.1 hypothetical protein -
SAST43_RS12150 2399405..2400004 - 600 WP_000162813.1 DsbA family protein -
SAST43_RS12155 2400023..2400385 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAST43_RS12160 2400640..2401890 + 1251 WP_001012227.1 FemA/FemB family glycyltransferase FmhA -
SAST43_RS12165 2401987..2402718 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SAST43_RS12170 2402715..2403434 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T57554 WP_000113262.1 NZ_CP012974:c2398881-2398615 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T57554 NZ_CP012974:c2398881-2398615 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT57554 WP_000584499.1 NZ_CP012974:c2399132-2398881 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT57554 NZ_CP012974:c2399132-2398881 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References