Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2137306..2137522 Replicon chromosome
Accession NZ_CP012974
Organism Staphylococcus aureus strain ST20130943

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAST43_RS10780 Protein ID WP_001802298.1
Coordinates 2137418..2137522 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2137306..2137361 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST43_RS10760 2133500..2134165 - 666 WP_001024093.1 SDR family oxidoreductase -
SAST43_RS10765 2134317..2134637 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAST43_RS10770 2134639..2135619 + 981 WP_000019745.1 CDF family zinc efflux transporter CzrB -
SAST43_RS10775 2135885..2136976 + 1092 WP_000495671.1 lytic regulatory protein -
- 2137306..2137361 + 56 - - Antitoxin
SAST43_RS10780 2137418..2137522 - 105 WP_001802298.1 hypothetical protein Toxin
SAST43_RS14415 2138202..2138360 + 159 WP_001792784.1 hypothetical protein -
SAST43_RS10785 2139018..2139875 - 858 WP_000370926.1 Cof-type HAD-IIB family hydrolase -
SAST43_RS10790 2139943..2140725 - 783 WP_000908175.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T57552 WP_001802298.1 NZ_CP012974:c2137522-2137418 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T57552 NZ_CP012974:c2137522-2137418 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT57552 NZ_CP012974:2137306-2137361 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References