Detailed information of TA system TA057544

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1802669..1802849
• Replicon: chromosome
• Accession: NZ_CP012974
• Organism: Staphylococcus aureus strain ST20130943

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SAST43_RS14675
• Protein ID: WP_001801861.1
• Coordinates: 1802669..1802764 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1802792..1802849 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAST43_RS08730	1797831..1798481	+	651	WP_072470537.1	excalibur calcium-binding domain-containing protein	-
SAST43_RS08735	1798562..1799557	+	996	WP_000070641.1	DUF4352 domain-containing protein	-
SAST43_RS08740	1799632..1800258	+	627	WP_000669026.1	hypothetical protein	-
SAST43_RS08745	1800299..1800640	+	342	WP_000627537.1	DUF3969 family protein	-
SAST43_RS08750	1800741..1801313	+	573	WP_000414215.1	hypothetical protein	-
SAST43_RS14320	1801512..1802524	-	1013	Protein_1677	IS3 family transposase	-
SAST43_RS14675	1802669..1802764	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1802792..1802849	-	58	-	-	Antitoxin
SAST43_RS08770	1802887..1802988	+	102	WP_001792025.1	hypothetical protein	-
SAST43_RS14680	1802966..1803127	-	162	Protein_1680	transposase	-
SAST43_RS08775	1803118..1803612	-	495	Protein_1681	transposase	-
SAST43_RS08780	1804064..1805293	-	1230	WP_047230715.1	restriction endonuclease subunit S	-
SAST43_RS08785	1805286..1806842	-	1557	WP_062909798.1	type I restriction-modification system subunit M	-
SAST43_RS08790	1807007..1807141	-	135	Protein_1684	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T57544 WP_001801861.1 NZ_CP012974:1802669-1802764 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T57544 NZ_CP012974:1802669-1802764 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT57544 NZ_CP012974:c1802849-1802792 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin