Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2390493..2391010 Replicon chromosome
Accession NZ_CP012972
Organism Staphylococcus aureus strain ST20130938

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag SAST38_RS12060 Protein ID WP_000113262.1
Coordinates 2390493..2390759 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAST38_RS12065 Protein ID WP_000584499.1
Coordinates 2390759..2391010 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST38_RS12035 2385934..2386470 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
SAST38_RS12040 2386704..2387528 - 825 WP_000572040.1 formate/nitrite transporter family protein -
SAST38_RS12045 2387745..2387927 - 183 WP_000079142.1 hypothetical protein -
SAST38_RS12050 2388014..2388481 - 468 WP_000153344.1 SRPBCC domain-containing protein -
SAST38_RS12055 2388667..2390199 - 1533 WP_062911937.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAST38_RS12060 2390493..2390759 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
SAST38_RS12065 2390759..2391010 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAST38_RS12070 2391175..2391276 - 102 Protein_2280 hypothetical protein -
SAST38_RS12075 2391283..2391882 - 600 WP_000162810.1 DsbA family protein -
SAST38_RS12080 2391901..2392263 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAST38_RS12085 2392518..2393768 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
SAST38_RS12090 2393865..2394596 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SAST38_RS12095 2394593..2395312 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T57539 WP_000113262.1 NZ_CP012972:c2390759-2390493 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T57539 NZ_CP012972:c2390759-2390493 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT57539 WP_000584499.1 NZ_CP012972:c2391010-2390759 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT57539 NZ_CP012972:c2391010-2390759 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References