Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-sprA1AS/-
Location 2135929..2136126 Replicon chromosome
Accession NZ_CP012972
Organism Staphylococcus aureus strain ST20130938

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAST38_RS10715 Protein ID WP_001802298.1
Coordinates 2136022..2136126 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2135929..2135967 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAST38_RS10695 2130948..2131268 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAST38_RS10700 2131270..2132250 + 981 WP_000019739.1 CDF family zinc efflux transporter CzrB -
SAST38_RS10705 2132516..2133607 + 1092 WP_000495672.1 hypothetical protein -
SAST38_RS10710 2133636..2135273 - 1638 Protein_2021 IS1182 family transposase -
- 2135929..2135967 + 39 - - Antitoxin
SAST38_RS10715 2136022..2136126 - 105 WP_001802298.1 hypothetical protein Toxin
SAST38_RS14325 2136806..2136964 + 159 WP_001792784.1 hypothetical protein -
SAST38_RS10720 2137623..2138480 - 858 WP_000370931.1 Cof-type HAD-IIB family hydrolase -
SAST38_RS10725 2138548..2139330 - 783 WP_000908174.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2133636..2135114 1478


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T57538 WP_001802298.1 NZ_CP012972:c2136126-2136022 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T57538 NZ_CP012972:c2136126-2136022 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 39 bp

>AT57538 NZ_CP012972:2135929-2135967 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References