Detailed information of TA system TA057519

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1753110..1753716
• Replicon: chromosome
• Accession: NZ_CP012969
• Organism: Psychrobacter sp. AntiMn-1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A1G6U2D0
• Locus tag: AOT82_RS07400
• Protein ID: WP_025643795.1
• Coordinates: 1753381..1753716 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AOT82_RS07395
• Protein ID: WP_025643793.1
• Coordinates: 1753110..1753391 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOT82_RS07350	1748128..1748388	+	261	WP_071002444.1	type II toxin-antitoxin system HicA family toxin	-
AOT82_RS07355	1748381..1748878	+	498	WP_071002446.1	type II toxin-antitoxin system HicB family antitoxin	-
AOT82_RS07360	1748893..1749141	+	249	WP_071002448.1	hypothetical protein	-
AOT82_RS07365	1749238..1750125	+	888	WP_071002450.1	N-acetylmuramoyl-L-alanine amidase	-
AOT82_RS07370	1750297..1751043	+	747	WP_071002451.1	pyridoxine 5'-phosphate synthase	-
AOT82_RS07375	1751069..1751818	+	750	WP_071002452.1	type 1 glutamine amidotransferase	-
AOT82_RS07380	1751834..1752037	+	204	WP_071002454.1	hypothetical protein	-
AOT82_RS07385	1752239..1752634	-	396	WP_071002456.1	hypothetical protein	-
AOT82_RS13830	1752794..1752931	-	138	WP_156770982.1	hypothetical protein	-
AOT82_RS07395	1753110..1753391	-	282	WP_025643793.1	helix-turn-helix domain-containing protein	Antitoxin
AOT82_RS07400	1753381..1753716	-	336	WP_025643795.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AOT82_RS07405	1753868..1757857	-	3990	WP_071002460.1	phosphoribosylformylglycinamidine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (43-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-84)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12769.62 Da
• Isoelectric Point: 8.3686

>T57519 WP_025643795.1 NZ_CP012969:c1753716-1753381 [Psychrobacter sp. AntiMn-1]
MLHFIETPIFTKQVLKLLDDEAYKELQENLINNPEQGDLIQGTGGVRKTRWALNQGKSGGIRIIYYFVNSQGIFFMLLAY
PKNKQASLSSEEKSGLYKLTQQIKEVYSHEQ

Nucleotide

• Length: 336 bp

>T57519 NZ_CP012969:c1753716-1753381 [Psychrobacter sp. AntiMn-1]
ATGTTACATTTCATCGAAACGCCAATATTTACTAAGCAAGTACTGAAACTATTAGATGATGAAGCTTATAAAGAGCTACA
GGAAAATCTAATCAATAATCCAGAACAAGGTGATTTGATTCAAGGTACAGGGGGCGTTCGAAAAACCAGATGGGCACTTA
ACCAAGGTAAGAGTGGCGGTATTCGGATTATCTATTATTTTGTGAATAGTCAAGGCATATTTTTTATGCTGCTCGCTTAT
CCGAAGAATAAACAAGCCTCTCTATCAAGCGAAGAGAAGTCTGGTTTATACAAACTGACTCAACAAATTAAAGAGGTGTA
TAGCCATGAGCAATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10359.68 Da
• Isoelectric Point: 9.8654

>AT57519 WP_025643793.1 NZ_CP012969:c1753391-1753110 [Psychrobacter sp. AntiMn-1]
MSNEFYDDLSTSLNQALAIAKGQAQPSRQFTHDVPSIKEIRTKTGLSQQQFADKLNISSRTLQNWEQGTRNPTGAAVTLM
RLLNKKPELIAEA

Nucleotide

• Length: 282 bp

>AT57519 NZ_CP012969:c1753391-1753110 [Psychrobacter sp. AntiMn-1]
ATGAGCAATGAATTTTACGATGATTTATCTACATCACTAAATCAAGCATTGGCGATTGCTAAAGGACAGGCTCAGCCTAG
CCGTCAGTTTACCCATGACGTGCCTAGTATTAAGGAAATAAGAACTAAGACAGGGCTATCGCAACAGCAGTTTGCCGATA
AACTTAATATCAGTTCGCGTACCTTACAAAATTGGGAGCAAGGTACTAGAAACCCAACAGGGGCTGCCGTCACATTAATG
CGCTTATTGAATAAAAAGCCTGAGTTAATTGCCGAAGCTTAA

Structures

Toxin

• AlphaFold DB: A0A1G6U2D0