Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 167221..167867 Replicon chromosome
Accession NZ_CP012959
Organism Aggregatibacter actinomycetemcomitans strain 624

Toxin (Protein)


Gene name higB Uniprot ID A0A5D0EMT1
Locus tag ACT75_RS00770 Protein ID WP_005552065.1
Coordinates 167517..167867 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID X2JT85
Locus tag ACT75_RS00765 Protein ID WP_005540827.1
Coordinates 167221..167520 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACT75_RS00760 164252..167185 + 2934 WP_005594956.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -
ACT75_RS00765 167221..167520 - 300 WP_005540827.1 helix-turn-helix transcriptional regulator Antitoxin
ACT75_RS00770 167517..167867 - 351 WP_005552065.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACT75_RS00775 168054..169637 - 1584 WP_005540820.1 peptide chain release factor 3 -
ACT75_RS00780 169994..170821 + 828 WP_005594959.1 hypothetical protein -
ACT75_RS00785 170909..172246 + 1338 WP_005540817.1 argininosuccinate synthase -
ACT75_RS00790 172437..172682 + 246 WP_061866519.1 YgjV family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13508.60 Da        Isoelectric Point: 9.9664

>T57499 WP_005552065.1 NZ_CP012959:c167867-167517 [Aggregatibacter actinomycetemcomitans]
MWAVILTERFETWLNQQSIKTQECVLANLVRLEHFGPNLARPYVDSVAGSIHSNMKELRVQHSGRAIRLFFAFDPKRRAI
VLCGGDKGNDKRFYRTMIRIADQELNHYLATMEQTK

Download         Length: 351 bp

>T57499 NZ_CP012959:c167867-167517 [Aggregatibacter actinomycetemcomitans]
ATGTGGGCGGTGATTTTAACGGAACGATTTGAAACTTGGTTAAATCAACAGTCGATAAAAACGCAGGAATGTGTTTTGGC
AAACTTGGTACGGTTGGAACATTTTGGTCCGAATTTAGCCCGTCCTTATGTAGATAGCGTAGCAGGGTCAATTCATAGCA
ACATGAAAGAACTACGCGTTCAGCATTCGGGAAGAGCAATTCGACTCTTTTTTGCTTTTGATCCAAAGCGTAGAGCCATT
GTTTTATGTGGTGGAGATAAAGGCAATGACAAGCGGTTTTACCGTACGATGATTAGAATTGCAGATCAAGAATTGAATCA
TTATTTGGCAACCATGGAGCAAACAAAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11342.12 Da        Isoelectric Point: 5.8598

>AT57499 WP_005540827.1 NZ_CP012959:c167520-167221 [Aggregatibacter actinomycetemcomitans]
MKTLQQVIDERSVESRQRIQTMAEDLILETGLQLLREELNISQQQLATILGVTQPAINQLEQRGNEIKLATLKRYIEAMG
GKLRLSVEMPDGHQRVFQI

Download         Length: 300 bp

>AT57499 NZ_CP012959:c167520-167221 [Aggregatibacter actinomycetemcomitans]
ATGAAAACATTACAACAAGTTATTGATGAACGTTCGGTAGAAAGCCGCCAACGTATTCAAACCATGGCGGAAGATTTAAT
TCTTGAAACCGGTTTGCAACTGTTGCGAGAAGAATTAAATATATCGCAACAACAATTAGCTACGATTTTAGGTGTAACTC
AACCTGCAATTAATCAACTGGAACAGCGTGGCAATGAAATTAAGCTTGCAACCCTCAAACGTTACATCGAAGCAATGGGC
GGTAAATTACGCCTTAGTGTAGAAATGCCTGATGGACATCAGCGGGTTTTTCAAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D0EMT1

Antitoxin

Source ID Structure
AlphaFold DB X2JT85

References