Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 225515..226034 Replicon chromosome
Accession NZ_CP012911
Organism Streptococcus suis strain NSUI060

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8M4E9
Locus tag APQ97_RS01290 Protein ID WP_002939009.1
Coordinates 225777..226034 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag APQ97_RS01285 Protein ID WP_002939010.1
Coordinates 225515..225775 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APQ97_RS01245 220700..221059 + 360 WP_004194560.1 ribonuclease P protein component -
APQ97_RS01250 221043..221855 + 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
APQ97_RS01255 221875..222870 + 996 WP_013730624.1 protein jag -
APQ97_RS01260 223038..223175 + 138 WP_002939016.1 50S ribosomal protein L34 -
APQ97_RS01265 223284..224066 + 783 WP_002939015.1 TatD family hydrolase -
APQ97_RS01270 224029..224619 + 591 WP_002939014.1 ribonuclease M5 -
APQ97_RS01275 224612..224980 + 369 WP_002939013.1 hypothetical protein -
APQ97_RS01280 224984..225439 + 456 WP_002939012.1 8-oxo-dGTP diphosphatase -
APQ97_RS01285 225515..225775 + 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
APQ97_RS01290 225777..226034 + 258 WP_002939009.1 Txe/YoeB family addiction module toxin Toxin
APQ97_RS01295 226048..226578 + 531 WP_002939008.1 DUF1697 domain-containing protein -
APQ97_RS01300 226562..227470 + 909 WP_074390583.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
APQ97_RS01305 227673..229403 + 1731 WP_061286095.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10321.83 Da        Isoelectric Point: 7.3119

>T57452 WP_002939009.1 NZ_CP012911:225777-226034 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEVDKLYILSL
KDHYG

Download         Length: 258 bp

>T57452 NZ_CP012911:225777-226034 [Streptococcus suis]
ATGGGAATCCATTTTACAGAGGATGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTCAAGCGAAT
CAATAAGATTATCAAGGATATGCAACGACATCCTTTTGAAGGCATTGCCAAACCAGAACCCTTGAAGTATGATTATCAGG
GTGCCTGGTCTCGGAGAATTGATGCCGAAAATCGGCTGATTTATATGGTAGAAGTAGATAAGCTGTATATTTTGTCTTTA
AAGGATCATTATGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT57452 WP_002939010.1 NZ_CP012911:225515-225775 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT57452 NZ_CP012911:225515-225775 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8M4E9

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References