Detailed information of TA system TA057437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3119333..3120011
• Replicon: chromosome
• Accession: NZ_CP012897
• Organism: Brevundimonas sp. DS20

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0P0DEC1
• Locus tag: JL11_RS15335
• Protein ID: WP_054766417.1
• Coordinates: 3119333..3119689 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JL11_RS15340
• Protein ID: WP_054766418.1
• Coordinates: 3119691..3120011 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JL11_RS15310	3114488..3114733	+	246	WP_054766412.1	DUF4160 domain-containing protein	-
JL11_RS15315	3114714..3114971	+	258	WP_054766413.1	DUF2442 domain-containing protein	-
JL11_RS15320	3115071..3116462	+	1392	WP_054766414.1	cytochrome P450	-
JL11_RS15325	3116622..3117641	+	1020	WP_054766415.1	glycosyltransferase family 4 protein	-
JL11_RS15330	3117739..3119274	+	1536	WP_197273400.1	alkaline phosphatase D family protein	-
JL11_RS15335	3119333..3119689	+	357	WP_054766417.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JL11_RS15340	3119691..3120011	+	321	WP_054766418.1	XRE family transcriptional regulator	Antitoxin
JL11_RS15345	3120061..3120882	-	822	WP_054766419.1	YmdB family metallophosphoesterase	-
JL11_RS15350	3120879..3121313	-	435	WP_054766420.1	PIN domain-containing protein	-
JL11_RS15355	3121313..3121555	-	243	WP_054766421.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
JL11_RS15360	3121602..3122144	-	543	WP_054766422.1	5-formyltetrahydrofolate cyclo-ligase	-
JL11_RS15365	3122426..3122743	-	318	WP_054766423.1	cell division protein ZapA	-
JL11_RS15370	3122743..3123039	-	297	WP_054766424.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13150.01 Da
• Isoelectric Point: 6.8819

>T57437 WP_054766417.1 NZ_CP012897:3119333-3119689 [Brevundimonas sp. DS20]
MPWAVSNHDEFDPEFDALPVEVQDELLAMTALLEVYGPRLGRPHADTLAGSRHANMKELRFKAADGVWRVAFAFDPERQA
ILLVAGDKAGAAQKRFYKGLIAKADSRFTSHLRALKET

Nucleotide

• Length: 357 bp

>T57437 NZ_CP012897:3119333-3119689 [Brevundimonas sp. DS20]
ATGCCATGGGCCGTCAGCAACCATGATGAGTTCGACCCAGAGTTCGACGCCCTCCCAGTCGAAGTCCAGGACGAGCTATT
GGCGATGACGGCGCTGTTGGAAGTCTATGGGCCCCGGCTGGGCCGCCCCCATGCCGACACCCTGGCAGGGTCAAGGCACG
CCAACATGAAGGAACTTCGGTTCAAGGCGGCCGACGGGGTCTGGCGGGTTGCGTTCGCATTTGATCCGGAGCGGCAGGCC
ATCCTGCTGGTCGCCGGCGACAAGGCAGGCGCGGCCCAGAAGCGATTCTACAAAGGCCTTATCGCCAAGGCGGACAGCCG
GTTCACCAGCCACTTGAGGGCGTTGAAGGAGACATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11662.48 Da
• Isoelectric Point: 7.2072

>AT57437 WP_054766418.1 NZ_CP012897:3119691-3120011 [Brevundimonas sp. DS20]
MGRTREEIMAALPEARRTRIDARAAELVGEVEGLKALRELAERSQEQIAQALGVKQPSVLKMERQADLYLSTLRRFVEAA
GGTLELRVELPGKGVLHLTGMGDISH

Nucleotide

• Length: 321 bp

>AT57437 NZ_CP012897:3119691-3120011 [Brevundimonas sp. DS20]
ATGGGTCGCACGCGCGAAGAGATCATGGCTGCGCTGCCGGAGGCCCGGCGGACGCGCATCGACGCCCGCGCCGCCGAACT
CGTGGGCGAAGTGGAAGGCCTGAAGGCGTTGCGCGAGCTCGCCGAACGCAGCCAGGAGCAGATCGCCCAGGCGCTTGGAG
TAAAGCAGCCTTCGGTGCTCAAGATGGAACGCCAGGCCGATCTCTACCTGTCCACTCTGCGCCGGTTCGTCGAGGCGGCC
GGCGGCACCCTTGAACTGCGCGTCGAACTGCCCGGAAAGGGCGTCCTTCACCTCACGGGCATGGGCGACATCAGCCACTG
A

Structures

Toxin

• AlphaFold DB: A0A0P0DEC1