Detailed information of TA system TA057380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 1624002..1624648
• Replicon: chromosome
• Accession: NZ_CP012871
• Organism: [Enterobacter] lignolyticus strain G5

Toxin (Protein)

• Gene name: higB
• Uniprot ID: E3G263
• Locus tag: AO703_RS07585
• Protein ID: WP_013366927.1
• Coordinates: 1624313..1624648 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AO703_RS07580
• Protein ID: WP_125451941.1
• Coordinates: 1624002..1624316 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AO703_RS07555	1619997..1620251	-	255	WP_013366933.1	hypothetical protein	-
AO703_RS07560	1620281..1621051	-	771	WP_062740759.1	molybdopterin-dependent oxidoreductase	-
AO703_RS07565	1621062..1621661	-	600	WP_062740760.1	cytochrome b/b6 domain-containing protein	-
AO703_RS07570	1621803..1622525	+	723	WP_013366930.1	response regulator transcription factor	-
AO703_RS07575	1622522..1623994	+	1473	WP_062740761.1	ATP-binding protein	-
AO703_RS07580	1624002..1624316	-	315	WP_125451941.1	transcriptional regulator	Antitoxin
AO703_RS07585	1624313..1624648	-	336	WP_013366927.1	hypothetical protein	Toxin
AO703_RS07590	1624776..1625507	-	732	WP_013366926.1	ABC transporter substrate-binding protein ArtJ	-
AO703_RS07595	1625679..1626347	-	669	WP_013366925.1	arginine ABC transporter permease ArtM	-
AO703_RS07600	1626347..1627063	-	717	WP_062740762.1	arginine ABC transporter permease ArtQ	-
AO703_RS07605	1627070..1627801	-	732	WP_013366923.1	arginine ABC transporter substrate-binding protein	-
AO703_RS07610	1627819..1628547	-	729	WP_062740763.1	arginine ABC transporter ATP-binding protein ArtP	-
AO703_RS07615	1628748..1629263	-	516	WP_062740764.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-87)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13266.40 Da
• Isoelectric Point: 8.8722

>T57380 WP_013366927.1 NZ_CP012871:c1624648-1624313 [[Enterobacter] lignolyticus]
MDAVFVEMPPFERHRAYYLSDESFGELQQLLMINPLAGDVIKHTGGLRKLRFVDIKRGKGQRGGLRVIYYWWQSKWQFLL
FTLYNKNEMVDLTQTQCEILHQMLEQRIRGE

Nucleotide

• Length: 336 bp

>T57380 NZ_CP012871:c1624648-1624313 [[Enterobacter] lignolyticus]
ATGGACGCGGTGTTTGTCGAGATGCCCCCTTTTGAGCGGCATCGTGCTTACTATCTTAGTGATGAGTCATTTGGTGAATT
GCAGCAATTACTGATGATCAATCCGCTTGCGGGCGATGTGATTAAGCATACGGGCGGCCTCAGAAAATTGCGCTTTGTCG
ATATCAAACGCGGCAAAGGTCAAAGAGGCGGACTTCGCGTTATCTATTACTGGTGGCAGAGCAAATGGCAGTTCCTGCTG
TTTACCCTCTATAACAAAAATGAGATGGTCGATCTGACCCAGACCCAATGTGAGATACTTCATCAAATGCTGGAACAACG
AATCCGGGGGGAATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12021.94 Da
• Isoelectric Point: 10.7083

>AT57380 WP_125451941.1 NZ_CP012871:c1624316-1624002 [[Enterobacter] lignolyticus]
IMSRDLFTELTEGMHAWQESNEGKRTLKTHRLATQDILLTAEDIRGIRRRLNLSQALFARYLHTALKTYQNWEQGVARPN
KQAMLLLRIVEKQPAALHLLATLS

Nucleotide

• Length: 315 bp

>AT57380 NZ_CP012871:c1624316-1624002 [[Enterobacter] lignolyticus]
ATAATGAGCCGGGATCTTTTTACTGAGCTTACCGAAGGAATGCACGCCTGGCAGGAGTCCAATGAAGGTAAGCGTACCCT
GAAAACACATCGTCTGGCGACGCAGGATATTCTGCTGACGGCGGAAGATATCAGAGGCATCCGCCGCCGTCTGAATCTTT
CACAGGCGTTGTTTGCGCGCTATCTGCATACCGCGCTGAAAACCTATCAGAACTGGGAACAGGGCGTCGCGAGACCGAAC
AAGCAGGCTATGCTGCTGCTGCGCATTGTGGAAAAACAACCTGCGGCGCTGCATCTGCTTGCCACTCTGAGCTAA

Structures

Toxin

• AlphaFold DB: A0A806X3J1