Detailed information of TA system TA057279

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 57020..57284
• Replicon: plasmid pCFSAN001588_002
• Accession: NZ_CP012835
• Organism: Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: E6BRV3
• Locus tag: CFSAN001588_RS23065
• Protein ID: WP_001303307.1
• Coordinates: 57132..57284 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	57020..57082 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFSAN001588_RS25745	52260..53084	-	825	WP_171815626.1	icmO-like type IV secretion system domain protein	-
CFSAN001588_RS25750	53150..54550	-	1401	WP_200909169.1	hypothetical protein	-
CFSAN001588_RS23055	54543..55613	-	1071	WP_023233614.1	IncI1-type conjugal transfer protein TrbB	-
CFSAN001588_RS23060	55632..56840	-	1209	WP_000121273.1	IncI1-type conjugal transfer protein TrbA	-
-	57020..57082	-	63	NuclAT_0	-	Antitoxin
-	57020..57082	-	63	NuclAT_0	-	Antitoxin
-	57020..57082	-	63	NuclAT_0	-	Antitoxin
-	57020..57082	-	63	NuclAT_0	-	Antitoxin
CFSAN001588_RS23065	57132..57284	+	153	WP_001303307.1	Hok/Gef family protein	Toxin
CFSAN001588_RS23070	57356..57607	-	252	WP_001291965.1	hypothetical protein	-
CFSAN001588_RS25755	58267..58404	-	138	WP_047088497.1	hypothetical protein	-
CFSAN001588_RS23075	58489..59673	-	1185	WP_077944741.1	transposase	-
CFSAN001588_RS24645	59732..60135	+	404	Protein_72	IS200/IS605 family transposase	-
CFSAN001588_RS25760	60197..60349	-	153	Protein_73	pilus assembly protein PilO	-
CFSAN001588_RS25135	60342..62016	-	1675	Protein_74	PilN family type IVB pilus formation outer membrane protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..62884	62884
	-	flank	IS/Tn	-	-	58489..59679	1190

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5817.21 Da
• Isoelectric Point: 8.7948

>T57279 WP_001303307.1 NZ_CP012835:57132-57284 [Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T57279 NZ_CP012835:57132-57284 [Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Nucleotide

• Length: 63 bp

>AT57279 NZ_CP012835:c57082-57020 [Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: A0A634Q5L1

Antitoxin