Detailed information of TA system TA057274

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1355..1619
• Replicon: plasmid pCFSAN001588_002
• Accession: NZ_CP012835
• Organism: Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: E6BRV3
• Locus tag: CFSAN001588_RS22740
• Protein ID: WP_001303307.1
• Coordinates: 1467..1619 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	1355..1417 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
-	1355..1417	-	63	NuclAT_1	-	Antitoxin
-	1355..1417	-	63	NuclAT_1	-	Antitoxin
-	1355..1417	-	63	NuclAT_1	-	Antitoxin
-	1355..1417	-	63	NuclAT_1	-	Antitoxin
CFSAN001588_RS22740	1467..1619	+	153	WP_001303307.1	Hok/Gef family protein	Toxin
CFSAN001588_RS22745	1691..1942	-	252	WP_001291965.1	hypothetical protein	-
CFSAN001588_RS25725	2601..2738	-	138	WP_047088497.1	hypothetical protein	-
CFSAN001588_RS22755	2783..4008	-	1226	Protein_4	transposase	-
CFSAN001588_RS24570	4067..4471	+	405	WP_001175009.1	IS200/IS605 family transposase	-
CFSAN001588_RS25730	4531..4686	-	156	Protein_6	pilus assembly protein PilO	-
CFSAN001588_RS22760	4679..6361	-	1683	WP_000748143.1	PilN family type IVB pilus formation outer membrane protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..62884	62884

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5817.21 Da
• Isoelectric Point: 8.7948

>T57274 WP_001303307.1 NZ_CP012835:1467-1619 [Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T57274 NZ_CP012835:1467-1619 [Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Nucleotide

• Length: 63 bp

>AT57274 NZ_CP012835:c1417-1355 [Salmonella enterica subsp. enterica serovar Cerro str. CFSAN001588]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: A0A634Q5L1

Antitoxin