Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1358547..1359198 Replicon chromosome
Accession NZ_CP012805
Organism Streptococcus anginosus strain J4211

Toxin (Protein)


Gene name higB Uniprot ID A0A0P0NA83
Locus tag SanJ4211_RS06755 Protein ID WP_003023734.1
Coordinates 1358833..1359198 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0P0NA18
Locus tag SanJ4211_RS06750 Protein ID WP_003023736.1
Coordinates 1358547..1358843 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SanJ4211_RS06735 1354116..1354712 - 597 WP_021001926.1 recombination mediator RecR -
SanJ4211_RS06740 1354723..1356783 - 2061 WP_021001927.1 penicillin-binding protein PBP2B -
SanJ4211_RS10125 1357146..1357313 - 168 WP_003023739.1 hypothetical protein -
SanJ4211_RS06745 1357320..1358525 - 1206 WP_003023737.1 hypothetical protein -
SanJ4211_RS06750 1358547..1358843 - 297 WP_003023736.1 helix-turn-helix transcriptional regulator Antitoxin
SanJ4211_RS06755 1358833..1359198 - 366 WP_003023734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SanJ4211_RS06760 1359473..1359652 - 180 WP_106079412.1 hypothetical protein -
SanJ4211_RS06765 1359990..1360517 + 528 Protein_1307 site-specific integrase -
SanJ4211_RS06770 1360675..1361367 - 693 WP_003023729.1 phosphoglycerate mutase -
SanJ4211_RS06775 1361508..1361969 - 462 WP_021001929.1 transcriptional repressor -
SanJ4211_RS06780 1362416..1363717 - 1302 WP_057489735.1 LysM peptidoglycan-binding domain-containing protein -
SanJ4211_RS06785 1363695..1363979 - 285 WP_057489736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1354116..1408655 54539


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14583.84 Da        Isoelectric Point: 10.1543

>T57252 WP_003023734.1 NZ_CP012805:c1359198-1358833 [Streptococcus anginosus]
VHNIYFYKDKNGNEPVLDYMRELASKKGKDSRIKLNKINDYIELLSQRGTRAGEPYIKHLDAEIWELRPLRDRILFVAWI
DGNFVLLHHFMKKTQKTPKREIEQAKRELRDLKERGLYNEK

Download         Length: 366 bp

>T57252 NZ_CP012805:c1359198-1358833 [Streptococcus anginosus]
GTGCATAATATCTATTTTTACAAAGATAAAAACGGGAATGAGCCGGTTTTAGATTATATGCGTGAACTTGCCAGCAAAAA
AGGCAAGGATAGTCGTATCAAACTAAACAAGATAAATGACTATATCGAACTACTAAGCCAACGTGGTACACGCGCAGGAG
AACCGTATATTAAGCATTTAGATGCTGAAATTTGGGAGCTTAGACCATTGAGGGATAGGATATTATTTGTTGCTTGGATT
GATGGCAACTTTGTATTGTTGCATCATTTTATGAAAAAGACGCAGAAAACACCAAAACGAGAAATTGAACAAGCAAAGCG
TGAATTACGCGACTTAAAAGAAAGAGGGCTATACAATGAAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10699.35 Da        Isoelectric Point: 4.8780

>AT57252 WP_003023736.1 NZ_CP012805:c1358843-1358547 [Streptococcus anginosus]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIDARNEKGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEGEQVS

Download         Length: 297 bp

>AT57252 NZ_CP012805:c1358843-1358547 [Streptococcus anginosus]
ATGAAAAATAGTGCAATTGGTAGTAACTGGAAAGATGTGAGAGCTGAACTTTTTTCCAAAGAGGAAATTTTGGAGAGTGA
TATGCGCGTGGCAATCATGAGTGAGCTGATTGATGCTAGAAATGAAAAAGGGATCAGTCAGAAAAAACTTGAGGAACTAA
GCGGAGTAAGTCAGCCAGTTATTGCTAGAATGGAAACAGGTAAGACAAGTCCACAACTTGATACTGTTTTAAAAGTCTTG
GCAAGTCTTGGGAAAACTTTGGCAGTTGTACCCTTAGAGGGCGAACAGGTAAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0NA83

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0NA18

References