Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 164049..164562 Replicon chromosome
Accession NZ_CP012805
Organism Streptococcus anginosus strain J4211

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0N7JDI1
Locus tag SanJ4211_RS01005 Protein ID WP_003027142.1
Coordinates 164049..164303 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0P0N6Y5
Locus tag SanJ4211_RS01010 Protein ID WP_003027139.1
Coordinates 164296..164562 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SanJ4211_RS09950 161798..161917 - 120 Protein_158 site-specific integrase -
SanJ4211_RS00985 162405..162662 + 258 WP_003027150.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SanJ4211_RS00990 162659..163015 + 357 Protein_160 type II toxin-antitoxin system death-on-curing family toxin -
SanJ4211_RS00995 163125..163400 - 276 Protein_161 helix-turn-helix transcriptional regulator -
SanJ4211_RS01000 163387..163767 - 381 WP_003027145.1 type II toxin-antitoxin system RelE/ParE family toxin -
SanJ4211_RS01005 164049..164303 - 255 WP_003027142.1 Txe/YoeB family addiction module toxin Toxin
SanJ4211_RS01010 164296..164562 - 267 WP_003027139.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SanJ4211_RS01015 165079..166476 + 1398 WP_021001204.1 MucBP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10455.90 Da        Isoelectric Point: 9.2753

>T57249 WP_003027142.1 NZ_CP012805:c164303-164049 [Streptococcus anginosus]
MFNFTEQAWKDYVSWQQEDKKILKRINRLIEDIKRNPFEGIGKPEPLKYRYSGAWSRRITDEQRLVYMVEKDEIYFLSFR
DHYT

Download         Length: 255 bp

>T57249 NZ_CP012805:c164303-164049 [Streptococcus anginosus]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAGGATAAAAAGATACTCAAACGTATCAA
TCGTTTAATAGAGGATATCAAACGGAATCCTTTTGAAGGGATTGGAAAGCCTGAACCCTTAAAATATCGTTATTCCGGTG
CTTGGTCTCGTAGAATTACAGATGAACAACGATTAGTCTATATGGTGGAAAAAGATGAGATTTATTTCTTATCCTTTAGA
GACCATTACACATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10475.03 Da        Isoelectric Point: 5.8648

>AT57249 WP_003027139.1 NZ_CP012805:c164562-164296 [Streptococcus anginosus]
MEAVVYSNFRNNLKHYMKKVNDEYEPLMVVNKNPDENIVVLSKKNWDSIQETIRLMNNEYLSDKVLSGMEQVKQKKTIQR
QLLEVEDV

Download         Length: 267 bp

>AT57249 NZ_CP012805:c164562-164296 [Streptococcus anginosus]
ATGGAAGCTGTCGTCTATTCAAATTTTAGAAACAATTTAAAACATTACATGAAAAAAGTCAACGATGAATATGAACCTCT
AATGGTTGTCAATAAAAATCCTGATGAAAATATTGTAGTCTTATCTAAGAAAAATTGGGATAGTATCCAAGAAACCATCC
GTCTAATGAATAACGAGTACCTTTCAGACAAGGTTCTATCAGGAATGGAACAAGTCAAGCAAAAGAAAACCATTCAACGC
CAATTATTAGAGGTGGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N7JDI1

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0N6Y5

References