Detailed information of TA system TA057239

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4314501..4314722
• Replicon: chromosome
• Accession: NZ_CP012802
• Organism: Escherichia coli O157:H7 strain WS4202

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: AO055_RS30735
• Protein ID: WP_001295224.1
• Coordinates: 4314501..4314608 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4314657..4314722 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AO055_RS22195	4309753..4310505	-	753	Protein_4213	cellulose biosynthesis protein BcsQ	-
AO055_RS22205	4310517..4310706	-	190	Protein_4214	YhjR family protein	-
AO055_RS22210	4310979..4312550	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
AO055_RS22215	4312547..4312738	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
AO055_RS22220	4312735..4314414	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
AO055_RS30735	4314501..4314608	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4314657..4314722	+	66	NuclAT_16	-	Antitoxin
-	4314657..4314722	+	66	NuclAT_16	-	Antitoxin
-	4314657..4314722	+	66	NuclAT_16	-	Antitoxin
-	4314657..4314722	+	66	NuclAT_16	-	Antitoxin
-	4314657..4314722	+	66	NuclAT_21	-	Antitoxin
-	4314657..4314722	+	66	NuclAT_21	-	Antitoxin
-	4314657..4314722	+	66	NuclAT_21	-	Antitoxin
-	4314657..4314722	+	66	NuclAT_21	-	Antitoxin
AO055_RS22235	4315084..4316355	+	1272	WP_001301684.1	amino acid permease	-
AO055_RS22240	4316385..4317389	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
AO055_RS22245	4317386..4318369	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
AO055_RS22250	4318380..4319282	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T57239 WP_001295224.1 NZ_CP012802:c4314608-4314501 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T57239 NZ_CP012802:c4314608-4314501 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT57239 NZ_CP012802:4314657-4314722 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin