Detailed information of TA system TA057196

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 376147..376327
• Replicon: chromosome
• Accession: NZ_CP012756
• Organism: Staphylococcus aureus strain JS395

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: ACH32_RS15165
• Protein ID: WP_001801861.1
• Coordinates: 376147..376242 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	376270..376327 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACH32_RS01860	371184..371810	+	627	WP_000669033.1	hypothetical protein	-
ACH32_RS01865	371851..372192	+	342	WP_060649610.1	DUF3969 family protein	-
ACH32_RS01870	372293..372865	+	573	WP_000414203.1	hypothetical protein	-
ACH32_RS01875	373063..373620	-	558	WP_000864140.1	ImmA/IrrE family metallo-endopeptidase	-
ACH32_RS01880	373805..373984	-	180	Protein_362	hypothetical protein	-
ACH32_RS01885	373992..374168	-	177	WP_000375476.1	hypothetical protein	-
ACH32_RS01890	374179..374562	-	384	WP_025174588.1	hypothetical protein	-
ACH32_RS01895	375249..375695	-	447	WP_000747807.1	DUF1433 domain-containing protein	-
ACH32_RS15165	376147..376242	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	376270..376327	-	58	-	-	Antitoxin
ACH32_RS15370	376459..376626	+	168	WP_001268925.1	hypothetical protein	-
ACH32_RS01900	377252..377695	-	444	WP_000731441.1	DUF1433 domain-containing protein	-
ACH32_RS01905	377695..378138	-	444	WP_060649611.1	DUF1433 domain-containing protein	-
ACH32_RS01910	378138..378563	-	426	WP_000260278.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T57196 WP_001801861.1 NZ_CP012756:376147-376242 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T57196 NZ_CP012756:376147-376242 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT57196 NZ_CP012756:c376327-376270 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin