Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2476132..2476802 Replicon chromosome
Accession NZ_CP012750
Organism Glutamicibacter halophytocola strain KLBMP 5180

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag AOZ07_RS11385 Protein ID WP_060702102.1
Coordinates 2476443..2476802 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag AOZ07_RS11380 Protein ID WP_060703428.1
Coordinates 2476132..2476437 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOZ07_RS11355 2471551..2472978 + 1428 WP_194943653.1 MFS transporter -
AOZ07_RS11360 2472995..2474167 + 1173 WP_084793226.1 amidohydrolase -
AOZ07_RS11370 2475074..2475609 - 536 Protein_2227 isochorismatase family protein -
AOZ07_RS11375 2475609..2475911 - 303 WP_060702101.1 HigA family addiction module antidote protein -
AOZ07_RS11380 2476132..2476437 - 306 WP_060703428.1 helix-turn-helix domain-containing protein Antitoxin
AOZ07_RS11385 2476443..2476802 - 360 WP_060702102.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOZ07_RS11390 2477294..2478025 + 732 WP_060702103.1 hypothetical protein -
AOZ07_RS11395 2478286..2479206 + 921 WP_060702104.1 toll/interleukin-1 receptor domain-containing protein -
AOZ07_RS18240 2479328..2479656 - 329 Protein_2233 Abi family protein -
AOZ07_RS11400 2479653..2480351 - 699 WP_060702105.1 GNAT family N-acetyltransferase -
AOZ07_RS11405 2480372..2480836 - 465 WP_207758452.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2468332..2515288 46956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-93)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13545.40 Da        Isoelectric Point: 4.4991

>T57174 WP_060702102.1 NZ_CP012750:c2476802-2476443 [Glutamicibacter halophytocola]
MWNVDIELIELIEVWLAELDVDSREQVVAAIELLEDSGPQLGRPIVDTVKASRHKNIKELRPGSSGKSELRILFAFDPER
AAIMLIAGDKAGDWQGWYEKNLPHADRLFDEHLDKIRGE

Download         Length: 360 bp

>T57174 NZ_CP012750:c2476802-2476443 [Glutamicibacter halophytocola]
TTGTGGAACGTGGACATCGAGCTCATCGAGCTCATCGAGGTTTGGCTTGCTGAGCTTGATGTTGATTCCCGGGAGCAAGT
GGTTGCCGCGATTGAACTGCTAGAGGATTCTGGGCCCCAGCTCGGACGACCCATTGTGGACACCGTAAAAGCATCTCGCC
ATAAGAATATAAAGGAACTTCGACCAGGTTCATCTGGCAAATCAGAATTGCGAATCTTGTTTGCGTTCGATCCGGAGCGG
GCGGCAATCATGCTAATTGCGGGCGATAAAGCTGGTGACTGGCAAGGCTGGTACGAGAAAAACCTTCCACATGCCGATCG
ATTGTTCGATGAACATTTAGACAAGATAAGAGGAGAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11550.22 Da        Isoelectric Point: 8.5142

>AT57174 WP_060703428.1 NZ_CP012750:c2476437-2476132 [Glutamicibacter halophytocola]
MAKSLKDFLAQNPVDRDRVEKHKQRMLAEVRAYRLRELREQAGLTQAELAERIGVGQRQVSKIEHGDLENAKIGTIRNYL
EAVGGELSLEYLMGDQRMQIA

Download         Length: 306 bp

>AT57174 NZ_CP012750:c2476437-2476132 [Glutamicibacter halophytocola]
TTGGCCAAGTCTCTTAAGGACTTTCTCGCTCAGAATCCAGTCGATCGGGACCGGGTCGAGAAGCACAAGCAGAGAATGCT
TGCGGAGGTTCGTGCCTATCGCTTGCGCGAATTGCGTGAACAGGCTGGACTCACTCAAGCTGAGCTCGCTGAGCGCATTG
GTGTGGGGCAGCGTCAAGTCTCGAAGATTGAGCATGGAGATCTTGAGAATGCAAAAATCGGCACAATCCGCAACTATTTG
GAAGCTGTCGGAGGGGAGCTGTCCTTGGAATACCTGATGGGCGATCAGCGGATGCAGATAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References