Detailed information of TA system TA057110

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 1450882..1451515
• Replicon: chromosome
• Accession: NZ_CP012739
• Organism: Vibrio vulnificus strain FORC_017

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A347UQS4
• Locus tag: FORC17_RS06630
• Protein ID: WP_012600340.1
• Coordinates: 1450882..1451214 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FORC17_RS06635
• Protein ID: WP_017049537.1
• Coordinates: 1451201..1451515 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC17_RS06595	1446941..1447222	+	282	WP_000086649.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FORC17_RS06600	1447219..1447506	+	288	WP_065090329.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FORC17_RS06605	1447668..1448141	+	474	WP_065090330.1	hypothetical protein	-
FORC17_RS23555	1448159..1448266	+	108	WP_081280308.1	DUF3265 domain-containing protein	-
FORC17_RS06610	1448274..1448705	+	432	WP_065090331.1	DUF2513 domain-containing protein	-
FORC17_RS25395	1449009..1449137	+	129	WP_000947521.1	DUF645 family protein	-
FORC17_RS25400	1449153..1449191	+	39	WP_108244118.1	hypothetical protein	-
FORC17_RS06620	1449389..1450171	+	783	WP_065090332.1	hypothetical protein	-
FORC17_RS23565	1450161..1450283	+	123	WP_197672403.1	DUF3265 domain-containing protein	-
FORC17_RS06625	1450335..1450655	+	321	WP_052298473.1	hypothetical protein	-
FORC17_RS23570	1450690..1450844	+	155	Protein_1257	DUF3265 domain-containing protein	-
FORC17_RS06630	1450882..1451214	+	333	WP_012600340.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC17_RS06635	1451201..1451515	+	315	WP_017049537.1	DNA-binding transcriptional regulator	Antitoxin
FORC17_RS23575	1451530..1451622	+	93	WP_005445734.1	DUF3265 domain-containing protein	-
FORC17_RS23580	1451984..1452106	+	123	WP_072611569.1	DUF3265 domain-containing protein	-
FORC17_RS06640	1452141..1452536	+	396	WP_038969916.1	DUF3465 domain-containing protein	-
FORC17_RS23585	1452537..1452665	+	129	Protein_1263	DUF3265 domain-containing protein	-
FORC17_RS06645	1452700..1453077	+	378	WP_065090333.1	hypothetical protein	-
FORC17_RS23590	1453100..1453192	+	93	WP_081280213.1	DUF3265 domain-containing protein	-
FORC17_RS23595	1453551..1453679	+	129	WP_081048123.1	DUF3265 domain-containing protein	-
FORC17_RS24825	1454022..1454150	+	129	WP_145923177.1	DUF3265 domain-containing protein	-
FORC17_RS23600	1454493..1454615	+	123	Protein_1268	DUF3265 domain-containing protein	-
FORC17_RS06650	1454644..1455111	+	468	WP_021276192.1	GNAT family N-acetyltransferase	-
FORC17_RS23605	1455093..1455200	+	108	WP_080553441.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1433137..1608704	175567
	-	inside	Integron	-	-	1431925..1601873	169948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (4-104)

Antitoxin

• Antitoxin MqsA/HigA-2 (24-101)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12906.76 Da
• Isoelectric Point: 10.0960

>T57110 WP_012600340.1 NZ_CP012739:1450882-1451214 [Vibrio vulnificus]
MKSVFVESTIFEKYRNEYLSDDEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKAFMEAWRNEQS

Nucleotide

• Length: 333 bp

>T57110 NZ_CP012739:1450882-1451214 [Vibrio vulnificus]
ATGAAAAGTGTATTTGTCGAATCAACCATATTTGAAAAGTACCGTAATGAATATCTCAGCGATGATGAGTTTAGGCTTTT
TCAAGCAGAGTTAATGTCTAACCCGAAGCAGGGTGACGTGATTCAAGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGTAAGGGCAAGCGTGGCGGCTCTCGCGTTATCTATTACTTCCTCGATGAGAAGCGTCGTTTCTACTTGCTGACG
ATTTACGGCAAGAATGAAATGTCCGACTTAACCGCAGACCAAAAGAAACAACTAAAGGCTTTTATGGAGGCGTGGCGTAA
TGAGCAATCGTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11704.17 Da
• Isoelectric Point: 6.3290

>AT57110 WP_017049537.1 NZ_CP012739:1451201-1451515 [Vibrio vulnificus]
MSNRDLFAELSSALVEAKEHSEGKLTLKTHQVNDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL

Nucleotide

• Length: 315 bp

>AT57110 NZ_CP012739:1451201-1451515 [Vibrio vulnificus]
ATGAGCAATCGTGATCTATTTGCGGAGTTAAGTTCAGCACTTGTTGAGGCTAAAGAGCATTCAGAGGGCAAGCTTACCCT
TAAAACTCATCAAGTTAACGACATCAGTGAGTTAAATATCTCACCTGATGAAATCGTGAGTATTCGAGAACAGTTTAATA
TGTCTCGTGGTGTATTTGCTCGTTTGTTGCACACATCATCTCGTACGTTAGAAAACTGGGAACAAGGTCGTAGCGCACCA
AATGGACAAGCAGTAACCCTTCTAAAGCTGGTTCAGCGTCATCCAGAGACCCTGTCGCACATCGCTGAGCTATAA

Structures

Toxin

• AlphaFold DB: A0A347UQS4