Detailed information of TA system TA057091

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2871435..2871660
• Replicon: chromosome
• Accession: NZ_CP012735
• Organism: Shigella flexneri 1a strain 0228

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: AOT98_RS15610
• Protein ID: WP_000813254.1
• Coordinates: 2871505..2871660 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2871435..2871493 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AOT98_RS15570	2866612..2867874	-	1263	Protein_2730	tyrosine-type recombinase/integrase	-
AOT98_RS15580	2868212..2869009	-	798	WP_001325918.1	DgsA anti-repressor MtfA	-
AOT98_RS15590	2869220..2870270	-	1051	Protein_2732	tyrosine-type recombinase/integrase	-
AOT98_RS15595	2870270..2870410	-	141	Protein_2733	DUF4224 domain-containing protein	-
AOT98_RS15600	2870437..2870853	+	417	WP_005069274.1	hypothetical protein	-
-	2871435..2871493	-	59	-	-	Antitoxin
AOT98_RS15610	2871505..2871660	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
AOT98_RS27570	2871828..2872106	+	279	WP_011069426.1	hypothetical protein	-
AOT98_RS15620	2872108..2873166	+	1059	WP_001265248.1	DUF968 domain-containing protein	-
AOT98_RS15625	2873167..2873532	+	366	WP_000140020.1	RusA family crossover junction endodeoxyribonuclease	-
AOT98_RS15630	2873529..2874217	+	689	Protein_2739	bacteriophage antitermination protein Q	-
AOT98_RS15655	2875013..2875228	+	216	WP_000839572.1	class II holin family protein	-
AOT98_RS15660	2875327..2876001	+	675	WP_004967157.1	IS66-like element accessory protein TnpA	-
AOT98_RS15665	2875998..2876348	+	351	WP_005049241.1	IS66 family insertion sequence element accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH9.8	2861575..2904287	42712

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T57091 WP_000813254.1 NZ_CP012735:2871505-2871660 [Shigella flexneri 1a]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T57091 NZ_CP012735:2871505-2871660 [Shigella flexneri 1a]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT57091 NZ_CP012735:c2871493-2871435 [Shigella flexneri 1a]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin