Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2871435..2871660 Replicon chromosome
Accession NZ_CP012735
Organism Shigella flexneri 1a strain 0228

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag AOT98_RS15610 Protein ID WP_000813254.1
Coordinates 2871505..2871660 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2871435..2871493 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOT98_RS15570 2866612..2867874 - 1263 Protein_2730 tyrosine-type recombinase/integrase -
AOT98_RS15580 2868212..2869009 - 798 WP_001325918.1 DgsA anti-repressor MtfA -
AOT98_RS15590 2869220..2870270 - 1051 Protein_2732 tyrosine-type recombinase/integrase -
AOT98_RS15595 2870270..2870410 - 141 Protein_2733 DUF4224 domain-containing protein -
AOT98_RS15600 2870437..2870853 + 417 WP_005069274.1 hypothetical protein -
- 2871435..2871493 - 59 - - Antitoxin
AOT98_RS15610 2871505..2871660 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
AOT98_RS27570 2871828..2872106 + 279 WP_011069426.1 hypothetical protein -
AOT98_RS15620 2872108..2873166 + 1059 WP_001265248.1 DUF968 domain-containing protein -
AOT98_RS15625 2873167..2873532 + 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
AOT98_RS15630 2873529..2874217 + 689 Protein_2739 bacteriophage antitermination protein Q -
AOT98_RS15655 2875013..2875228 + 216 WP_000839572.1 class II holin family protein -
AOT98_RS15660 2875327..2876001 + 675 WP_004967157.1 IS66-like element accessory protein TnpA -
AOT98_RS15665 2875998..2876348 + 351 WP_005049241.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 2861575..2904287 42712


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T57091 WP_000813254.1 NZ_CP012735:2871505-2871660 [Shigella flexneri 1a]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T57091 NZ_CP012735:2871505-2871660 [Shigella flexneri 1a]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT57091 NZ_CP012735:c2871493-2871435 [Shigella flexneri 1a]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References